The roles of polymers in mRNA delivery

P Huang, H Deng, Y Zhou, X Chen - Matter, 2022 - cell.com
Summary mRNA therapy, which possesses distinctive advantages over DNA and protein-
based therapies, has immense potential for diverse applications, including mRNA vaccines …

Surface-functionalized PEGylated nanoparticles deliver messenger RNA to pulmonary immune cells

X Ke, L Shelton, Y Hu, Y Zhu, E Chow… - … applied materials & …, 2020 - ACS Publications
Nanoparticles designed as messenger RNA (mRNA) carriers to deliver gene medicine have
shown great potential to change the way lung disease states are managed. Controlling their …

Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery

P Huang, H Deng, C Wang, Y Zhou… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly
scalable therapeutic approach that involves technologies for both mRNA itself and the …

mRNA nanodelivery systems: targeting strategies and administration routes

M Yuan, Z Han, Y Liang, Y Sun, B He… - Biomaterials …, 2023 - spj.science.org
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid
(mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention …

Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy

P Karmacharya, BR Patil, JO Kim - Journal of pharmaceutical investigation, 2022 - Springer
Background Cancer remains a serious health concern worldwide, and different approaches
are being developed for its treatment. The strategy to use the immune system as an …

Establishing preferred product characterization for the evaluation of RNA vaccine antigens

C Poveda, AB Biter, ME Bottazzi, U Strych - Vaccines, 2019 - mdpi.com
The preferred product characteristics (for chemistry, control, and manufacture), in addition to
safety and efficacy, are quintessential requirements for any successful therapeutic …

Scope and challenges of nanoparticle-based mRNA delivery in cancer treatment

ME Karim, ST Haque, H Al-Busaidi, A Bakhtiar… - Archives of pharmacal …, 2022 - Springer
Messenger RNA (mRNA) recently emerged as an appealing alternative to treat and prevent
diseases ranging from cancer and Alzheimer's disease to COVID-19 with significant clinical …

Advances in nanoparticle-based mRNA delivery for liver cancer and liver-associated infectious diseases

S Chung, CM Lee, M Zhang - Nanoscale horizons, 2023 - pubs.rsc.org
The liver is a vital organ that functions to detoxify the body. Liver cancer and infectious
diseases such as influenza and malaria can fatally compromise liver function. mRNA …

Nonviral delivery systems of mRNA vaccines for cancer gene therapy

Y Wang, R Zhang, L Tang, L Yang - Pharmaceutics, 2022 - mdpi.com
In recent years, the use of messenger RNA (mRNA) in the fields of gene therapy,
immunotherapy, and stem cell biomedicine has received extensive attention. With the …

mRNA COVID-19 vaccines and long-lived plasma cells: a complicated relationship

G Giannotta, N Giannotta - Vaccines, 2021 - mdpi.com
mRNA COVID-19 vaccines have hegemonized the world market, and their administration to
the population promises to stop the pandemic. However, the waning of the humoral immune …