Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

The biochemical basis of microRNA targeting efficacy

SE McGeary, KS Lin, CY Shi, TM Pham, N Bisaria… - Science, 2019 - science.org
INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …

[HTML][HTML] A high-resolution temporal atlas of the SARS-CoV-2 translatome and transcriptome

D Kim, S Kim, J Park, HR Chang, J Chang… - Nature …, 2021 - nature.com
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which infected> 200 million people resulting in> 4 million deaths. However, temporal …

[HTML][HTML] The regulatory impact of RNA-binding proteins on microRNA targeting

S Kim, S Kim, HR Chang, D Kim, J Park, N Son… - Nature …, 2021 - nature.com
Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently
identified> 1,500 human RNA-binding proteins (RBPs), there are only a handful of RBPs …

A comprehensive, cell specific microRNA catalogue of human peripheral blood

S Juzenas, G Venkatesh, M Hübenthal… - Nucleic acids …, 2017 - academic.oup.com
With this study, we provide a comprehensive reference dataset of detailed miRNA
expression profiles from seven types of human peripheral blood cells (NK cells, B …

A step-by-step microRNA guide to cancer development and metastasis

GS Markopoulos, E Roupakia, M Tokamani… - Cellular Oncology, 2017 - Springer
Background Cancer is one of the leading causes of mortality. The neoplastic transformation
of normal cells to cancer cells is caused by a progressive accumulation of genetic and …

[HTML][HTML] MicroRNAs from plants to animals, do they define a new messenger for communication?

Z Li, R Xu, N Li - Nutrition & metabolism, 2018 - Springer
MicroRNAs (miRNAs), a class of single-stranded non-coding RNA of about 22 nucleotides,
are potent regulators of gene expression existing in both plants and animals. Recent studies …

MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

S Lorente-Cebrián, P González-Muniesa… - Clinical …, 2019 - portlandpress.com
Obesity is a metabolic condition usually accompanied by insulin resistance (IR), type 2
diabetes (T2D), and dyslipidaemia, which is characterised by excessive fat accumulation …

[HTML][HTML] The relationship of human tissue microRNAs with those from body fluids

C Cui, Q Cui - Scientific reports, 2020 - nature.com
It is known that many microRNAs (miRNAs) stably exist in various body fluids, however, the
relationship of body fluids miRNAs (BF-miRNAs) with those from tissues (T-miRNAs) …