[HTML][HTML] Inflammasomes as therapeutic targets in human diseases

Y Li, H Huang, B Liu, Y Zhang, X Pan, XY Yu… - Signal transduction and …, 2021 - nature.com
Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

[HTML][HTML] The ageing brain: molecular and cellular basis of neurodegeneration

S Azam, ME Haque, R Balakrishnan, IS Kim… - Frontiers in cell and …, 2021 - frontiersin.org
Ageing is an inevitable event in the lifecycle of all organisms, characterized by progressive
physiological deterioration and increased vulnerability to death. Ageing has also been …

[HTML][HTML] Novel therapeutic approaches for Alzheimer's disease: an updated review

TW Yu, HY Lane, CH Lin - International journal of molecular sciences, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease and accounts for
most cases of dementia. The prevalence of AD has increased in the current rapidly aging …

[HTML][HTML] Neurodegenerative disease and the NLRP3 inflammasome

JA Holbrook, HH Jarosz-Griffiths, E Caseley… - Frontiers in …, 2021 - frontiersin.org
The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …

[HTML][HTML] Regulated cell death: discovery, features and implications for neurodegenerative diseases

J Cui, S Zhao, Y Li, D Zhang, B Wang, J Xie… - Cell Communication and …, 2021 - Springer
Regulated cell death (RCD) is a ubiquitous process in living organisms that is essential for
tissue homeostasis or to restore biological balance under stress. Over the decades, various …

[HTML][HTML] Roles and mechanisms of gut microbiota in patients with Alzheimer's disease

S Wu, X Liu, R Jiang, X Yan, Z Ling - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common age-related progressive neurodegenerative
disease, characterized by a decline in cognitive function and neuronal loss, and is caused …

[HTML][HTML] Gasdermin D-mediated pyroptosis: mechanisms, diseases, and inhibitors

Z Dai, WC Liu, XY Chen, X Wang, JL Li… - Frontiers in …, 2023 - frontiersin.org
Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …

The role of the immune system in Alzheimer's disease

KM Wu, YR Zhang, YY Huang, Q Dong, L Tan… - Ageing research …, 2021 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disorder where the
accumulation of amyloid plaques and the formation of tau tangles are the prominent …

[HTML][HTML] Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling

Y Li, Q Jiang - Frontiers in Immunology, 2023 - frontiersin.org
Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …

Quercitrin rapidly alleviated depression-like behaviors in lipopolysaccharide-treated mice: The involvement of PI3K/AKT/NF-κB signaling suppression and CREB …

Y Sun, H Zhang, Z Wu, X Yu, Y Yin, S Qian… - ACS chemical …, 2021 - ACS Publications
Quercitrin (Qc) is a well-known flavonoid compound that exerts anti-inflammation effects on
various diseases. The present study aimed to investigate the antidepressant-like response …