Quercitrin rapidly alleviated depression-like behaviors in lipopolysaccharide-treated mice: The involvement of PI3K/AKT/NF-κB signaling suppression and CREB …

Y Sun, H Zhang, Z Wu, X Yu, Y Yin, S Qian… - ACS chemical …, 2021 - ACS Publications
Quercitrin (Qc) is a well-known flavonoid compound that exerts anti-inflammation effects on
various diseases. The present study aimed to investigate the antidepressant-like response …

[HTML][HTML] Targeting CSF-1R represents an effective strategy in modulating inflammatory diseases

C Xiang, H Li, W Tang - Pharmacological Research, 2023 - Elsevier
Abstract Colony-stimulating factor-1 receptor (CSF-1R), also known as FMS kinase, is a type
I single transmembrane protein mainly expressed in myeloid cells, such as monocytes …

Pyroptosis and degenerative diseases of the elderly

J Zhou, J Qiu, Y Song, T Liang, S Liu, C Ren… - Cell Death & …, 2023 - nature.com
Pyroptosis is a recently described mechanism of programmed cell death mediated by
proteins of the gasdermin family. Widely recognized signaling cascades include the …

Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling

Y Li, Q Jiang - Frontiers in Immunology, 2023 - frontiersin.org
Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …

[HTML][HTML] Astragaloside IV: A promising natural neuroprotective agent for neurological disorders

M Yao, L Zhang, L Wang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Neurological disorders are characterized by high morbidity, disability, and mortality rates,
which seriously threaten human health. However, clinically satisfactory agents for treatment …

Celastrol inhibits rheumatoid arthritis through the ROS-NF-κB-NLRP3 inflammasome axis

M Jing, J Yang, L Zhang, J Liu, S Xu, M Wang… - International …, 2021 - Elsevier
Emerging evidence indicates that NOD-like receptor protein 3 (NLRP3) inflammasome-
induced inflammation plays a critical role in the pathogenesis of rheumatoid arthritis (RA) …

Myelin in Alzheimer's disease: culprit or bystander?

M Maitre, H Jeltsch-David, NG Okechukwu… - Acta Neuropathologica …, 2023 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder with neuronal and synaptic
losses due to the accumulation of toxic amyloid β (Αβ) peptide oligomers, plaques, and …

Ferroptosis, pyroptosis, and cuproptosis in Alzheimer's disease

Q Wang, J Sun, T Chen, S Song, Y Hou… - ACS Chemical …, 2023 - ACS Publications
Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative
disorder characterized by progressive cognitive dysfunction. Epidemiological investigation …

Can we treat neuroinflammation in Alzheimer's disease?

S Sánchez-Sarasúa, I Fernández-Pérez… - International Journal of …, 2020 - mdpi.com
Alzheimer's disease (AD), considered the most common type of dementia, is characterized
by a progressive loss of memory, visuospatial, language and complex cognitive abilities. In …

Targeting NLRP3-mediated neuroinflammation in Alzheimer's disease treatment

J Barczuk, N Siwecka, W Lusa… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common cause of dementia in the general population
and, to date, constitutes a major therapeutic challenge. In the pathogenesis of AD …