Ginkgolide B inactivates the NLRP3 inflammasome by promoting autophagic degradation to improve learning and memory impairment in Alzheimer's disease
L Shao, C Dong, D Geng, Q He, Y Shi - Metabolic Brain Disease, 2022 - Springer
The NLR family, pyrin domain containing 3 (NLRP3) inflammasome drives the progression
of Alzheimer's disease (AD). Ginkgolide B (GB) is a potential anti-inflammatory compound …
of Alzheimer's disease (AD). Ginkgolide B (GB) is a potential anti-inflammatory compound …
Chinese herbal extracts exert neuroprotective effect in Alzheimer's disease mouse through the dopaminergic synapse/apoptosis signaling pathway
Q Huang, C Zhang, S Qu, S Dong, Q Ma… - Frontiers in …, 2022 - frontiersin.org
Background: Alzheimer's disease (AD) as an age-related, irreversible neurodegenerative
disease, characterized by cognitive dysfunction, has become progressively serious with a …
disease, characterized by cognitive dysfunction, has become progressively serious with a …
Degradation of NLRP3 by p62‐dependent‐autophagy improves cognitive function in Alzheimer's disease by maintaining the phagocytic function of microglia
D Zhang, Y Zhang, J Pan, J Cao, X Sun… - CNS Neuroscience …, 2023 - Wiley Online Library
Background Activation of the NLRP3 inflammasome promotes microglia to secrete
inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and …
inflammatory cytokines and induce pyroptosis, leading to impaired phagocytic and …
Depichering the effects of astragaloside IV on AD‐like phenotypes: a systematic and experimental investigation
X Wang, F Gao, W Xu, Y Cao, J Wang… - Oxidative medicine and …, 2021 - Wiley Online Library
Astragaloside IV (AS‐IV) is an active component in Astragalus membranaceus with the
potential to treat neurodegenerative diseases, especially Alzheimer's diseases (ADs) …
potential to treat neurodegenerative diseases, especially Alzheimer's diseases (ADs) …
Transcutaneous Electrical Nerve Stimulation (TENS) alleviates brain ischemic injury by regulating neuronal oxidative stress, pyroptosis, and mitophagy
Z Tan, F Dong, L Wu, Y Feng, M Zhang… - Mediators of …, 2023 - Wiley Online Library
Background. As a noninvasive treatment, transcutaneous electrical nerve stimulation (TENS)
has been utilized to treat various diseases in clinic. However, whether TENS can be an …
has been utilized to treat various diseases in clinic. However, whether TENS can be an …
The emerging roles of absent in melanoma 2 (AIM2) inflammasome in central nervous system disorders
YK Li, JG Chen, F Wang - Neurochemistry International, 2021 - Elsevier
As a double-stranded DNA (dsDNA) sensor, the PYHIN family member absent in melanoma
2 (AIM2) is an essential component of the inflammasome families. Activation of AIM2 by …
2 (AIM2) is an essential component of the inflammasome families. Activation of AIM2 by …
The emerging role of autophagy-associated lncRNAs in the pathogenesis of neurodegenerative diseases
Y Jiang, N Xu - International Journal of Molecular Sciences, 2023 - mdpi.com
Neurodegenerative diseases (NDDs) have become a significant global public health
problem and a major societal burden. The World Health Organization predicts that NDDs will …
problem and a major societal burden. The World Health Organization predicts that NDDs will …
Knockout of Sirt2 alleviates traumatic brain injury in mice
W Wang, QY Gong, L Cai, Y Jing… - Neural Regeneration …, 2023 - journals.lww.com
Abstract Sirtuin 2 (SIRT2) inhibition or Sirt2 knockout in animal models protects against the
development of neurodegenerative diseases and cerebral ischemia. However, the role of …
development of neurodegenerative diseases and cerebral ischemia. However, the role of …
NLRP3 inflammasome of microglia promotes A1 astrocyte transformation, neo-neuron decline and cognition impairment in endotoxemia
T Xiao, H Ji, X Shangguan, S Qu, Y Cui, J Xu - … and Biophysical Research …, 2022 - Elsevier
Infection, predominantly induced by gram-negative bacteria, is a critical health problem and
a leading cause of death worldwide. Advance of techniques, such as antibiotics and life …
a leading cause of death worldwide. Advance of techniques, such as antibiotics and life …
Pyroptosis as a candidate therapeutic target for Alzheimer's disease
Y Huang, X Li, G Luo, J Wang, R Li, C Zhou… - Frontiers in Aging …, 2022 - frontiersin.org
Pyroptosis is a form of cell death mediated by inflammasomes and gasdermins, and the
relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing …
relevance of pyroptosis to neurodegenerative diseases is currently receiving increasing …