MET receptor tyrosine kinase as an autism genetic risk factor

Y Peng, M Huentelman, C Smith, S Qiu - International review of …, 2013 - Elsevier
In this chapter, we will briefly discuss recent literature on the role of MET receptor tyrosine
kinase (RTK) in brain development and how perturbation of MET signaling may alter normal …

[HTML][HTML] Link-level functional connectivity neuroalterations in autism spectrum disorder: a developmental resting-state fMRI study

L Borràs-Ferrís, Ú Pérez-Ramírez, D Moratal - Diagnostics, 2019 - mdpi.com
Autism spectrum disorder (ASD) is a neurological and developmental disorder whose late
diagnosis is based on subjective tests. In seeking for earlier diagnosis, we aimed to find …

The pleiotropic MET receptor network: circuit development and the neural-medical interface of autism

KL Eagleson, Z Xie, P Levitt - Biological psychiatry, 2017 - Elsevier
People with autism spectrum disorder and other neurodevelopmental disorders (NDDs) are
behaviorally and medically heterogeneous. The combination of polygenicity and gene …

Hepatocyte growth factor–c-MET signaling mediates the development of nonsensory structures of the Mammalian Cochlea and hearing

S Shibata, T Miwa, HH Wu, P Levitt… - Journal of …, 2016 - Soc Neuroscience
The stria vascularis is a nonsensory structure that is essential for auditory hair cell function
by maintaining potassium concentration of the scala media. During mouse embryonic …

[HTML][HTML] Transcriptional regulation of the MET receptor tyrosine kinase gene by MeCP2 and sex-specific expression in autism and Rett syndrome

JT Plummer, OV Evgrafov, MY Bergman, M Friez… - Translational …, 2013 - nature.com
Single nucleotide variants (SNV) in the gene encoding the MET receptor tyrosine kinase
have been associated with an increased risk for autism spectrum disorders (ASD). The MET …

[HTML][HTML] Developmental heterochrony and the evolution of autistic perception, cognition and behavior

B Crespi - BMC medicine, 2013 - Springer
Background Autism is usually conceptualized as a disorder or disease that involves
fundamentally abnormal neurodevelopment. In the present work, the hypothesis that a suite …

[HTML][HTML] Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder

I Garcia-Martínez, C Sánchez-Mora, M Pagerols… - Translational …, 2016 - nature.com
Attention deficit and hyperactivity disorder (ADHD) is a prevalent neurodevelopmental
disorder characterized by impairment to sustain attention and inability to control impulses …

[HTML][HTML] Enrichment of Elevated Plasma F2t-Isoprostane Levels in Individuals with Autism Who Are Stratified by Presence of Gastrointestinal Dysfunction

P Gorrindo, CJ Lane, EB Lee, BA McLaughlin, P Levitt - PloS one, 2013 - journals.plos.org
Etiology is unknown in the majority of individuals with autism spectrum disorder (ASD). One
strategy to investigate pathogenesis is to stratify this heterogeneous disorder based on a …

[HTML][HTML] Systematic review and meta-analysis: multimodal functional and anatomical neural alterations in autism spectrum disorder

Z Guo, X Tang, S Xiao, H Yan, S Sun, Z Yang, L Huang… - Molecular Autism, 2024 - Springer
Background This meta-analysis aimed to explore the most robust findings across numerous
existing resting-state functional imaging and voxel-based morphometry (VBM) studies on the …

Genome-wide identification of regulatory sequences undergoing accelerated evolution in the human genome

X Dong, X Wang, F Zhang, W Tian - Molecular Biology and …, 2016 - academic.oup.com
Accelerated evolution of regulatory sequence can alter the expression pattern of target
genes, and cause phenotypic changes. In this study, we used DNase I hypersensitive sites …