The cardiovascular research and clinical communities are ideally positioned to address the
epidemic of noncommunicable causes of death, as well as advance our understanding of …

Liddle syndrome is an inherited form of low-renin hypertension, transmitted with an
autosomal dominant pattern. The molecular basis of Liddle syndrome resides in germline …

Hypertension is the leading cause of cardiovascular disease in the United States, affecting
up to one-third of adults. When compared to other ethnic or racial groups in the United …

Hypertension is a significant risk factor for heart disease, stroke and other cardiovascular
diseases and an estimated 970 million people worldwide suffer from the disease resulting in …

Objective The prevalence of primary aldosteronism in unselected hypertensive patients is
currently unknown. We investigated the frequency of positive screening results for primary …

The plasma proteome is highly dynamic and variable, composed of proteins derived from
surrounding tissues and cells. To investigate the complex processes that control the …

Abstract Purpose of the Review The main goal of this article is to discuss how the
development of state-of-the-art technology has made it possible to address fundamental …

A substantial proportion of patients with hypertension have a low or suppressed renin. This
phenotype of low-renin hypertension (LRH) may be the manifestation of inherited genetic …

Chronic kidney disease (CKD) triggers the risk of developing uremic cardiomyopathy as
characterized by cardiac hypertrophy, fibrosis and functional impairment. Traditionally …

BACKGROUND Blockade of the renin–angiotensin system (RAS) represents a main strategy
in the therapy of heart failure with reduced ejection fraction (HFrEF), but the role of active …