BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …

Translational regulation plays an important role in gene expression and function. Although
the transcriptional dynamics of mouse preimplantation embryos have been well …

Chromatin accessibility is integral to the process by which transcription factors (TFs) read out
cis-regulatory DNA sequences, but it is difficult to differentiate between TFs that drive …

Upon fertilization, embryos undergo chromatin reprogramming and genome activation;
however, the mechanisms that regulate these processes are poorly understood. Here, we …

Translation regulation is critical for early mammalian embryonic development. However,
previous studies had been restricted to bulk measurements, precluding precise …

Pioneer factors are a group of transcription factors with important roles in gene regulation
during development. Their unique ability to bind to compacted chromatin, promoting its …

During the maternal-to-zygotic transition (MZT), multiple mechanisms precisely control
massive decay of maternal mRNAs. N 6-methyladenosine (m 6 A) is known to regulate …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Insect eggs are exposed to a plethora of abiotic and biotic threats. Their survival depends on
both an innate developmental program and genetically determined protective traits provided …