Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC),
contributing to early metastasis and poor patient survival. Compared to the localized tumors …

Long non-coding RNAs have gained attention in recent years as they were shown to play
crucial roles in the regulation of cellular processes, but the understanding of the exact …

Dysregulation of MOF (also known as MYST1, KAT8), a highly conserved H4K16
acetyltransferase, plays important roles in human cancers. However, its expression and …

Chronic liver injury induces the activation of hepatic stellate cells (HSCs) into myofibroblasts,
which produce excessive amounts of extracellular matrix (ECM), resulting in tissue fibrosis. If …

Pancreatic adenocarcinoma (PC), one of the most fatal diseases, usually generates a poor
prognosis in advanced stages. N6-methyladenosine modification has emerged as a crucial …

IL-6 signaling plays a crucial role in the survival and metastasis of skin cancer. NEDD4L acts
as a suppressor of IL-6 signaling by targeting GP130 degradation. However, the effects of …

The incidence rate of human hepatocellular carcinoma (HCC) is approximately three times
higher in males than in females. A better understanding of the mechanisms underlying HCC …

The ubiquitin-proteasome system (UPS) is a fundamental regulatory mechanism in cells,
vital for maintaining cellular homeostasis, compiling signaling transduction, and determining …

Simple Summary NEDD4 family members have been investigated to play contributory role in
carcinogenesis. In this review article, we have exclusively focused on the regulation and …

Pancreatic cancer is a clinically challenging disease with a poor survival rate and is one of
the leading causes of cancer‐related morbidity. It is highly resistant to treatment and …