Characterized by a complex pathophysiology that includes the intraneuronal formation of
neurofibrillary tangles and the extracellular deposition of β-amyloid plaques, Alzheimer's …

Introduction Hesperidin is a flavanone glycoside occurring in high levels in citrus species. It
is among the most significant natural anti-oxidants employed often in pharmaceuticals for …

The low bioaccessibility of hesperetin and piperine hampers their application as therapeutic
agents. Piperine has the ability to improve the bioavailability of many compounds when co …

The present study reports amorphous solid dispersions (ASDs) of hesperidin (Hes) prepared
by ball milling to improve its solubility and apparent solubility over the unmodified …

Sorafenib, a multikinase inhibitor is used to treat hepatocellular and renal carcinoma.
However, a low solubility impedes its bioavailability and thus, effectiveness. This study aims …

Constructing carrier materials with polysaccharides to enhance the solubility of insoluble
active ingredients is a crucial strategy for improving bioavailability. This research …

The study aimed to synthesize 7, 7-dimethyl-10-aryl,-7, 8-dihydro-5H-indeno-[1, 2-b]-
quinoline-9, 11 (6H, 10H)‑dione nanoparticles (IDQNPs) and to explore their biological …

This study has investigated the extraction process of hesperidin, a natural flavonoid found in
the peel of two citrus fruits. In this research, for the first time, citrus peel wastes of bitter …

Citrus polyphenols can modulate gut microbiota and such bi-directional interaction that can
yield metabolites such as short-chain fatty acids (SCFAs) to aid in gut homeostasis. Such …

Treating chemoresistant and metastatic colon cancers faces major difficulties. Due to their
high biocompatibility and magnetic property, Iron oxide nanoparticles have gained attention …