Left ventricular remodeling after myocardial infarction: from physiopathology to treatment

SA Leancă, D Crișu, AO Petriș, I Afrăsânie, A Genes… - Life, 2022 - mdpi.com
Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …

Myocardial ischemia/reperfusion: translational pathophysiology of ischemic heart disease

G Heusch - Med, 2024 - cell.com
Ischemic heart disease is the greatest health burden and most frequent cause of death
worldwide. Myocardial ischemia/reperfusion is the pathophysiological substrate of ischemic …

[HTML][HTML] Outcomes in diabetic patients treated with SGLT2-Inhibitors with acute myocardial infarction undergoing PCI: The SGLT2-I AMI PROTECT Registry

P Paolisso, L Bergamaschi, F Gragnano… - Pharmacological …, 2023 - Elsevier
Aims To investigate in-hospital and long-term prognosis in T2DM patients presenting with
acute myocardial infarction (AMI) treated with SGLT2-I versus other oral anti-diabetic agents …

Extracellular matrix/glycopeptide hybrid hydrogel as an immunomodulatory niche for endogenous cardiac repair after myocardial infarction

P Kong, J Dong, W Li, Z Li, R Gao, X Liu… - Advanced …, 2023 - Wiley Online Library
The treatment of myocardial infarction (MI) remains a substantial challenge due to excessive
inflammation, massive cell death, and restricted regenerative potential, leading to …

Cardioprotective properties of kaempferol: a review

Y Kamisah, J Jalil, NM Yunos, S Zainalabidin - Plants, 2023 - mdpi.com
Cardiac diseases, such as myocardial infarction and heart failure, have become a major
clinical problem globally. The accumulating data demonstrate that bioactive compounds with …

[HTML][HTML] Treatment strategies of acute myocardial infarction: updates on revascularization, pharmacological therapy, and beyond

Y Saito, K Oyama, K Tsujita, S Yasuda, Y Kobayashi - Journal of cardiology, 2023 - Elsevier
Owing to recent advances in early reperfusion strategies, pharmacological therapy,
standardized care, and the identification of vulnerable patient subsets, the prognosis of …

[HTML][HTML] Novel therapeutic strategies to reduce reperfusion injury after acute myocardial infarction

A Schäfer, T König, J Bauersachs, M Akin - Current Problems in Cardiology, 2022 - Elsevier
For almost 30 years, urgent revascularization termed primary percutaneous coronary
intervention has been a cornerstone of modern care for acute myocardial infarction (AMI). It …

A self‐sustaining antioxidant strategy for effective treatment of myocardial infarction

Q Sun, H Ma, J Zhang, B You, X Gong… - Advanced …, 2023 - Wiley Online Library
Myocardial infarction (MI) is the leading cause of death worldwide and can lead to the loss of
cardiac function and heart failure. Reactive oxygen species (ROS) play a key role in the …

Localized delivery of anti-inflammatory agents using extracellular matrix-nanostructured lipid carriers hydrogel promotes cardiac repair post-myocardial infarction

X Wang, H Shi, S Huang, Y Zhang, X He, Q Long… - Biomaterials, 2023 - Elsevier
A challenge in treating cardiac injury is the low heart-specificity of the drugs. Nanostructured
lipid carriers (NLCs) are a relatively new format of lipid nanoparticles which have been used …

Germacrone mitigates cardiac remodeling by regulating PI3K/AKT-mediated oxidative stress, inflammation, and apoptosis

Z Fang, F Yushanjiang, G Wang, X Zheng… - International …, 2023 - Elsevier
Cardiac remodeling is a common consequence of cardiovascular diseases and is closely
associated with oxidative stress, inflammation, and apoptosis. Germacrone, a bioactive …