Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

IN THE LATE 1980s and early 1990s, the elucidation of the molecular basis of acute
promyelocytic leukemia (APL) emerged as a paradigm for the connection between the …

Circadian rhythms govern a large array of metabolic and physiological functions. The central
clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its …

The molecular machinery that governs circadian rhythmicity comprises proteins whose
interplay generates time-specific transcription of clock genes. The role of chromatin …

The requirements for transcriptional activation by RNA polymerase II were examined using
chromatin templates assembled in vitro and a transcription system composed of the human …

TFIID is a large multiprotein complex that initiates assembly of the transcription machinery. It
is unclear how TFIID recognizes promoters in vivo when templates are nucleosome-bound …

A protein module called the WW domain recognizes and binds to a short oligopeptide called
the PY motif, PPxY, to mediate protein–protein interactions. The PY motif is present in the …

Steroid receptors and coactivator proteins are thought to stimulate gene expression by
facilitating the assembly of basal transcription factors into a stable preinitiation complex …

Reversible acetylation of core histone tails plays an important role in the regulation of
eukaryotic transcription, in the formation of repressive chromatin complexes, and in the …

An important event in gene expression is the covalent modification of histone proteins. We
have found that the mammalian transcriptional repressor Sin3 (mSin3) exists in a complex …