Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Peptides as multifunctional players in cancer therapy

SMP Vadevoo, S Gurung, HS Lee… - … & Molecular Medicine, 2023 - nature.com
Peptides exhibit lower affinity and a shorter half-life in the body than antibodies. Conversely,
peptides demonstrate higher efficiency in tissue penetration and cell internalization than …

Drug conjugates for targeting regulatory T cells in the tumor microenvironment: guided missiles for cancer treatment

J Yang, H Bae - Experimental & Molecular Medicine, 2023 - nature.com
Within the tumor microenvironment (TME), regulatory T cells (Tregs) play a key role in
suppressing anticancer immune responses; therefore, various strategies targeting Tregs are …

Recent advances in the peptide-based biosensor designs

Y Xiao, T Zhang, H Zhang - Colloids and Surfaces B: Biointerfaces, 2023 - Elsevier
Biosensors have rapidly emerged as a high-sensitivity and convenient detection method.
Among various types of biosensors, optical and electrochemical are the most commonly …

Improving the efficacy of peptide vaccines in cancer immunotherapy

F Zahedipour, K Jamialahmadi, P Zamani… - International …, 2023 - Elsevier
Peptide vaccines have shown great potential in cancer immunotherapy by targeting tumor
antigens and activating the patient's immune system to mount a specific response against …

[HTML][HTML] Engineered exosomes for cancer theranostics: Next-generation tumor targeting

VP Chavda, VV Sugandhi, CV Pardeshi, RJ Patil… - Journal of Drug Delivery …, 2023 - Elsevier
Exosomes are multivesicular bodies of which the plasma membrane fuse to release the
caring moiety into the surrounding body fluids. They are best known for their function in …

[HTML][HTML] Advances in targeted therapy for pancreatic cancer

L Xing, L Lv, J Ren, H Yu, X Zhao, X Kong… - Biomedicine & …, 2023 - Elsevier
Pancreatic cancer (PC) represents a group of malignant tumours originating from pancreatic
duct epithelial cells and acinar cells, and the 5-year survival rate of PC patients is only …

Peptide–Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics

TT Dean, J Jelú-Reyes, ALC Allen… - Journal of Medicinal …, 2024 - ACS Publications
Building on recent advances in peptide science, medicinal chemists have developed a
hybrid class of bioconjugates, called peptide–drug conjugates, that demonstrate improved …

Peptide-drug conjugates: A new paradigm for targeted cancer therapy

M Wang, J Liu, M Xia, L Yin, L Zhang, X Liu… - European Journal of …, 2024 - Elsevier
Peptide-drug conjugates (PDCs) are the new hope for targeted therapy after antibody-drug
conjugates (ADCs). Compared with ADCs, the core advantages of PDCs are enhanced …

Drug delivery strategies for the treatment of pancreatic cancer

O Olajubutu, OD Ogundipe, A Adebayo, SK Adesina - Pharmaceutics, 2023 - mdpi.com
Pancreatic cancer is fast becoming a global menace and it is projected to be the second
leading cause of cancer-related death by 2030. Pancreatic adenocarcinomas, which …