An updated patent review of metallo-β-lactamase inhibitors (2020–2023)
ABSTRACT Introduction Metallo-β-lactamases (MBLs) are enzymes produced by bacteria
that confer resistance to most β-lactam antibiotics, including carbapenems, which have the …
that confer resistance to most β-lactam antibiotics, including carbapenems, which have the …
Recent advances in β-lactamase inhibitor chemotypes and inhibition modes
R Li, X Chen, C Zhou, QQ Dai, L Yang - European journal of medicinal …, 2022 - Elsevier
The effectiveness of β-lactam antibiotics is increasingly influenced by serine β-lactamases
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …
(SBLs) and metallo-β-lactamases (MBLs), which can hydrolyze β-lactam antibiotics. The …
Optimization of 1, 2, 4-triazole-3-thiones toward broad-spectrum metallo-β-lactamase inhibitors showing potent synergistic activity on VIM-and NDM-1-producing …
A Legru, F Verdirosa, Y Vo-Hoang… - Journal of Medicinal …, 2022 - ACS Publications
Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …
carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to …
A fragment-based drug discovery strategy applied to the identification of NDM-1 β-lactamase inhibitors
J Caburet, B Boucherle, S Bourdillon… - European Journal of …, 2022 - Elsevier
Hydrolysis of β-lactam drugs, a major class of antibiotics, by serine or metallo-β-lactamases
(SBL or MBL) is one of the main mechanisms for antibiotic resistance. New Delhi Metallo-β …
(SBL or MBL) is one of the main mechanisms for antibiotic resistance. New Delhi Metallo-β …
[HTML][HTML] The development of New Delhi metallo-β-lactamase-1 inhibitors since 2018
X Gu, M Zheng, L Chen, H Li - Microbiological Research, 2022 - Elsevier
New Delhi metallo-β-lactamase-1 (NDM-1) can hydrolyze almost all antibiotics of the β-
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …
lactam group, resulting in the generation of multidrug resistant bacteria. Besides its broad …
Coexistence of blaNDM-1 and blaIMP-4 in One Novel Hybrid Plasmid Confers Transferable Carbapenem Resistance in an ST20-K28 Klebsiella pneumoniae
X Jia, P Jia, Y Zhu, W Yu, X Li, J Xi, X Liu… - Frontiers in …, 2022 - frontiersin.org
Objectives We identified a novel hybrid plasmid simultaneously carrying bla NDM-1 and bla
IMP-4 in an ST20-K28 carbapenem-resistant Klebsiella pneumoniae (CRKP) strain AZS099 …
IMP-4 in an ST20-K28 carbapenem-resistant Klebsiella pneumoniae (CRKP) strain AZS099 …
Recent developments to cope the antibacterial resistance via β-lactamase inhibition
Z Iqbal, J Sun, H Yang, J Ji, L He, L Zhai, J Ji, P Zhou… - Molecules, 2022 - mdpi.com
Antibacterial resistance towards the β-lactam (BL) drugs is now ubiquitous, and there is a
major global health concern associated with the emergence of new β-lactamases (BLAs) as …
major global health concern associated with the emergence of new β-lactamases (BLAs) as …
In Vitro and In Vivo Development of a β-Lactam-Metallo-β-Lactamase Inhibitor: Targeting Carbapenem-Resistant Enterobacterales
BK Peters, N Reddy, M Shungube… - ACS Infectious …, 2023 - ACS Publications
β-lactams are the most prescribed class of antibiotics due to their potent, broad-spectrum
antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the …
antimicrobial activities. However, alarming rates of antimicrobial resistance now threaten the …
1, 2, 4-Triazole-3-thione analogues with an arylakyl group at position 4 as metallo-β-lactamase inhibitors
L Gavara, F Verdirosa, L Sevaille, A Legru… - Bioorganic & medicinal …, 2022 - Elsevier
Abstract Metallo-β-lactamases (MBLs) represent an increasingly serious threat to public
health because of their increased prevalence worldwide in relevant opportunistic Gram …
health because of their increased prevalence worldwide in relevant opportunistic Gram …
Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors
N Reddy, L Girdhari, M Shungube, AC Gouws… - Antibiotics, 2023 - mdpi.com
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes
have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One …
have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One …