[HTML][HTML] IL-15 in T-cell responses and immunopathogenesis

H Lee, SH Park, EC Shin - Immune Network, 2024 - ncbi.nlm.nih.gov
IL-15 belongs to the common gamma chain cytokine family and has pleiotropic
immunological functions. IL-15 is a homeostatic cytokine essential for the development and …

[HTML][HTML] Innate-like T cells in liver disease

AYP Yang, K Wistuba-Hamprecht, TF Greten… - Trends in Immunology, 2024 - cell.com
Mammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT),
natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have …

[HTML][HTML] Evolution of T cells in the cancer-resistant naked mole-rat

TD Lin, ND Rubinstein, NL Fong, M Smith… - Nature …, 2024 - nature.com
Naked mole-rats (NMRs) are best known for their extreme longevity and cancer resistance,
suggesting that their immune system might have evolved to facilitate these phenotypes …

STAT5 is essential for inducing the suppressive subset and attenuate cytotoxicity of Vδ2+ T cells in acute myeloid leukemia

C Cheng, S Liang, K Yue, N Wu, Z Li, T Dong, X Dong… - Cancer Letters, 2024 - Elsevier
Under the sustained exposure to tumor microenvironment, effector lymphocytes may
transform into the suppressive populations. γδ T cells are recognized as a crucial mediator …

8th Sino-German symposium on immunology: fostering mutual trust and collaborative endeavors for advancing immunological science

B Huang, T Bopp, G Li - Cellular & Molecular Immunology, 2024 - nature.com
The Sino-German Symposium on Immunology was jointly initiated by the Chinese Society of
Immunology and the German Society of Immunology (DGFI) and was supported by the Sino …

[HTML][HTML] Advancements in γδT cell engineering: paving the way for enhanced cancer immunotherapy

M Yuan, W Wang, I Hawes, J Han, Z Yao… - Frontiers in …, 2024 - frontiersin.org
Comprising only 1-10% of the circulating T cell population, γδT cells play a pivotal role in
cancer immunotherapy due to their unique amalgamation of innate and adaptive immune …

[HTML][HTML] Novel insights into regulation of butyrophilin molecules: critical components of cancer immunosurveillance by γδ T cells

D Kabelitz - Cellular & Molecular Immunology, 2024 - nature.com
Members of the butyrophilin (BTN) family of transmembrane molecules play an important
role in the activation of human γδ T cells. In recent years, it has been discovered that …

[HTML][HTML] γδ T cells and the PD-1/PD-L1 axis: a love–hate relationship in the tumor microenvironment

J Liu, M Wu, Y Yang, Z Wang, S He, X Tian… - Journal of Translational …, 2024 - Springer
Gamma delta (γδ) T cells demonstrate strong cytotoxicity against diverse cancer cell types in
an MHC-independent manner, rendering them promising contenders for cancer therapy …

The Evolving Role of Dendritic Cells in Atherosclerosis

S Britsch, H Langer, D Duerschmied… - International Journal of …, 2024 - mdpi.com
Atherosclerosis, a major contributor to cardiovascular morbidity and mortality, is
characterized by chronic inflammation of the arterial wall. This inflammatory process is …

The therapeutic role of γδT cells in TNBC

W Li, X Zhao, C Ren, S Gao, Q Han, M Lu… - Frontiers in …, 2024 - frontiersin.org
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that presents significant
therapeutic challenges due to the absence of estrogen receptor (ER), progesterone receptor …