Resveratrol-phospholipid complex (Phytosome®)(RSVP) was found better aqueous soluble
and permeable than free resveratrol (RSV). RSVPs were incorporated in polymeric patch …

Extensive gut metabolism is often associated with the risk of low and variable bioavailability.
The prediction of the fraction of drug escaping gut wall metabolism as well as transporter …

Non-absorbable small-molecule drugs targeted to the gut represent an alternative approach
to safe, non-systemic therapeutics. Such drugs remain confined to the gastrointestinal tract …

Phytochemicals found in food have revealed noteworthy roles in treating and managing a
large number of human diseases. The structure, source, bioavailability, pharmacokinetics …

Abstract Purpose Tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) properties
of single ascending doses (SADs) and multiple ascending doses (MADs) of PF-06260414, a …

A multiple-unit formulation for time-dependent colonic release of insulin was obtained by
coating insulin and sodium glycocholate immediate-release minitablets with:(i) Methocel® …

Pain is one of the most prevalent and difficult to manage symptoms in cancer patients, and
conventional drugs present a range of adverse reactions. The development of β …

Echinacoside (ECH) is one of the representative phenylethanoid glycosides. It is widely
present in plants and exhibits various bioactivities. However, the extremely low oral …

Abstract Resveratrol trimethyl ether (trans-3, 5, 4'-trimethoxystilbene, RTE) is a naturally
occurring and pharmacologically active resveratrol derivative. To evaluate its suitability as a …

This review projects the prospects and issues faced by solid lipid nanoparticles (SLNs) in
current scenarios, specially related to its clinical implementation and effectiveness. We re …