Primary liver cancer, which consists predominantly of hepatocellular carcinoma (HCC), is
the fifth most common cancer worldwide and the third most common cause of cancer …

Mutations in TP53, the gene that encodes the tumour suppressor p53, are found in 50% of
human cancers, and increased levels of its negative regulators MDM2 and MDM4 (also …

Hepatocellular carcinoma (HCC) is one of the most frequent human malignancies worldwide
with very poor prognosis. It is generally accepted that the progression of HCC is a long-term …

Liver cancer is the second most frequent cause of cancer-related death globally. The main
histological subtype is hepatocellular carcinoma (HCC), which is derived from hepatocytes …

Understanding genetic aberrations in cancer leads to discovery of new targets for cancer
therapies. The genomic landscape of hepatocellular carcinoma (HCC) has not been fully …

Purpose: A single nucleotide polymorphism (SNP) in the promoter region of MDM2 gene,
SNP309, has recently been shown to be associated with accelerated tumor formation in both …

Hepatocellular carcinoma and extrahepatic malignancies can complicate the course of
autoimmune hepatitis, and these occurrences may increase in frequency as the survival of …

Human hepatocellular carcinoma (HCC) is the fifth most common cancer and is associated
with poor prognosis worldwide. The molecular mechanisms underlying the pathogenesis of …

Background Whether increased expression of the tumor suppressor protein p53 indicates a
p53 gene mutation in hepatocellular carcinoma (HCC) remains unclear. We conducted a …

Genetic and epigenetic alterations play prominent roles in hepatocarcinogenesis and their
appearance varies depending on etiological factors, race and tumor progression …