Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Alzheimer's disease (AD) is a neurodegenerative disease with a high incidence rate. The
main pathological features of AD are β-amyloid plaques (APs), which are formed by β …

The pathological hallmark of Alzheimer disease is deposition of amyloid-β protein (Aβ) in the
brain. Telmisartan is a unique angiotensin II receptor blocker with peroxisome proliferator …

Some of the best biomarkers of age-related cognitive decline are closely linked to synaptic
function and plasticity. This review highlights several age-related synaptic alterations as they …

Recently, as a drug target in cancer treatment, the superfamily of glutathione S‐transferase
(GSTs, EC 2.5. 1.18) have been invited considerable interest by scientists. In particular, as …

Background: Epidemiological evidence has associated Alzheimer's disease (AD) with
vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of …

We examined the possibility that continuous activation of the human brain renin-angiotensin
system causes cognitive impairment, using human renin (hRN) and human angiotensinogen …

The classical renin–angiotensin system (RAS), known as the angiotensin (Ang)-converting
enzyme (ACE)/Ang II/Ang II type 1 (AT1) receptor axis, induces various organ damages …

There is a growing interest in identifying natural food ingredients that may serve to prevent
dementia such as that due to Alzheimer disease (AD). Peptides derived from food proteins …

We examined the possibility that direct stimulation of the angiotensin II type 2 (AT2) receptor
by a newly generated direct AT2 receptor agonist, Compound 21 (C21), enhances cognitive …