Role of toll‐like receptors in modulation of cytokine storm signaling in SARS‐CoV‐2‐induced COVID‐19

M Manik, RK Singh - Journal of medical virology, 2022 - Wiley Online Library
Balanced immune regulation is crucial for recognizing an invading pathogen, its killing, and
elimination. Toll‐like receptors (TLRs) are the key regulators of the innate immune system. It …

The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential …

H Zalpoor, A Akbari, A Samei… - Cellular & Molecular …, 2022 - Springer
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and
finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe …

[HTML][HTML] Flavonoids against the SARS-CoV-2 induced inflammatory storm

A Liskova, M Samec, L Koklesova, SM Samuel… - Biomedicine & …, 2021 - Elsevier
The disease severity of COVID-19, especially in the elderly and patients with co-morbidities,
is characterized by hypercytokinemia, an exaggerated immune response associated with an …

[HTML][HTML] A glimpse of the first eight months of the COVID-19 literature on Microsoft academic graph: themes, citation contexts, and uncertainties

C Chen - Frontiers in research metrics and analytics, 2020 - frontiersin.org
As scientists worldwide search for answers to the overwhelmingly unknown behind the
deadly pandemic, the literature concerning COVID-19 has been growing exponentially …

[HTML][HTML] Tomato (Solanum lycopersicum L.) seed: A review on bioactives and biomedical activities

M Kumar, M Tomar, DJ Bhuyan, S Punia… - Biomedicine & …, 2021 - Elsevier
The processing of tomato fruit into puree, juices, ketchup, sauces, and dried powders
generates a significant amount of waste in the form of tomato pomace, which includes seeds …

T helper type (Th1/Th2) responses to SARS-CoV-2 and influenza A (H1N1) virus: From cytokines produced to immune responses

E Aleebrahim-Dehkordi, B Molavi, M Mokhtari… - Transplant …, 2022 - Elsevier
Cytokines produced by T helper cells (T h cells) have essential roles in the body's defense
against viruses. Type 1 T helper (Th1) cells are essential for the host defense toward …

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

DJM Fernández-Ayala, P Navas… - Experimental gerontology, 2020 - Elsevier
SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication

Q Ning, D Wu, X Wang, D Xi, T Chen, G Chen… - … and Targeted Therapy, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) is a highly transmissible disease
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that poses a …

Calming the storm: natural immunosuppressants as adjuvants to target the cytokine storm in COVID-19

AE Peter, BV Sandeep, BG Rao… - Frontiers in …, 2021 - frontiersin.org
The COVID-19 pandemic has caused a global health crisis, with no specific antiviral to treat
the infection and the absence of a suitable vaccine to prevent it. While some individuals …

An antioxidant enzyme therapeutic for COVID‐19

M Qin, Z Cao, J Wen, Q Yu, C Liu, F Wang… - Advanced …, 2020 - Wiley Online Library
The COVID‐19 pandemic has taken a significant toll on people worldwide, and there are
currently no specific antivirus drugs or vaccines. Herein it is a therapeutic based on catalase …