[HTML][HTML] Potential role of IFN-α in COVID-19 patients and its underlying treatment options

L Yang, J Wang, P Hui, TO Yarovinsky, S Badeti… - Applied Microbiology …, 2021 - Springer
Abstract The coronavirus disease (COVID-19) caused by a severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly worldwide. Given that this …

Antiviral and possible prophylactic significance of myricetin for COVID-19

PK Agrawal, C Agrawal… - Natural Product …, 2023 - journals.sagepub.com
Myricetin (3, 5, 7, 3′, 4′, 5′-hexahydroxyflavone), a common dietary flavonoid, has been
reported for its roles in improving health due to various pharmacological activities, such as …

Vandetanib blocks the cytokine storm in SARS-CoV-2-infected mice

AC Puhl, GF Gomes, S Damasceno, EJ Fritch… - ACS …, 2022 - ACS Publications
The portfolio of SARS-CoV-2 small molecule drugs is currently limited to a handful that are
either approved (remdesivir), emergency approved (dexamethasone, baricitinib, paxlovid …

[HTML][HTML] Peptide-based vaccines and therapeutics for COVID-19

PV Bagwe, PV Bagwe, SS Ponugoti… - International Journal of …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been prevalent in the
humans since 2019 and has given rise to a pandemic situation. With the discovery and …

Pyronaridine protects against SARS-CoV-2 infection in mouse

AC Puhl, GF Gomes, S Damasceno… - ACS Infectious …, 2022 - ACS Publications
There are currently relatively few small-molecule antiviral drugs that are either approved or
emergency-approved for use against severe acute respiratory coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Deferiprone: a forty-year-old multi-targeting drug with possible activity against COVID-19 and diseases of similar symptomatology

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2022 - mdpi.com
The need for preparing new strategies for the design of emergency drug therapies against
COVID-19 and similar diseases in the future is rather urgent, considering the high rate of …

[HTML][HTML] Optimal cut points of N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) in patients with COVID-19

M Chehrazi, H Yavarpour, F Jalali, M Saravi… - The Egyptian Heart …, 2022 - Springer
Background COVID19 patients may suffer from multiple cardiovascular complications.
Recently, N-terminal of the prohormone brain natriuretic peptide (NT-proBNP) was a …

[HTML][HTML] A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases

Y Wang, SC Pang, Y Yang - Immunity & Ageing, 2021 - Springer
Elderly patients with cardiovascular diseases account for a large proportion of Corona virus
Disease 2019 (COVID-19) related deaths. COVID-19, as a new coronavirus, mainly targets …

Metronidazole, acyclovir and tetrahydrobiopterin may be promising to treat COVID-19 patients, through interaction with interleukin-12

B Farasati Far, D Bokov, G Widjaja… - Journal of …, 2023 - Taylor & Francis
COVID-19 patients have shown overexpressed serum levels of several pro-inflammatory
cytokines, leading to a high mortality rate due to numerous complications. Also, previous …

Genetic polymorphisms of IL6 gene–174G> C and–597G> A are associated with the risk of COVID‐19 severity

S Verma, S Verma, FH Khan, Z Siddiqi… - International Journal …, 2023 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19) is pro‐inflammatory disorder characterized
by acute respiratory distress syndrome. Interleukin‐6, a cytokine secreted by macrophages …