Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors
Dozens of variants in the gene for the homeodomain transcription factor (TF) cone-rod
homeobox (CRX) are linked with human blinding diseases that vary in their severity and age …
homeobox (CRX) are linked with human blinding diseases that vary in their severity and age …
[HTML][HTML] Active learning of enhancer and silencer regulatory grammar in photoreceptors
RZ Friedman, A Ramu, S Lichtarge, CA Myers… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cis-regulatory elements (CREs) direct gene expression in health and disease, and models
that can accurately predict their activities from DNA sequences are crucial for biomedicine …
that can accurately predict their activities from DNA sequences are crucial for biomedicine …
Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element
D Srivastava, P Gowribidanur-Chinnaswamy, P Gaur… - Structure, 2024 - cell.com
Two retinal transcription factors, cone-rod homeobox (CRX) and neural retina leucine zipper
(NRL), cooperate functionally and physically to control photoreceptor development and …
(NRL), cooperate functionally and physically to control photoreceptor development and …
Active learning of enhancer and silencer regulatory grammar in a developing neural tissue
RZ Friedman, A Ramu, S Lichtarge, Y Wu, L Tripp… - bioRxiv, 2023 - biorxiv.org
Cis-regulatory elements (CREs) direct gene expression in health and disease, and models
that can accurately predict their activities from DNA sequences are crucial for biomedicine …
that can accurately predict their activities from DNA sequences are crucial for biomedicine …
The emergence and evolution of gene expression in genome regions replete with regulatory motifs
Gene regulation is essential for life and controlled by regulatory DNA. Mutations can modify
the activity of regulatory DNA, and also create new regulatory DNA, a process called …
the activity of regulatory DNA, and also create new regulatory DNA, a process called …
Promoter motifs facilitate as well as impede the emergence and evolution of gene expression
Gene regulation is essential for life and controlled by regulatory DNA. Mutations can modify
the activity of regulatory DNA, and also create new regulatory DNA, a process called …
the activity of regulatory DNA, and also create new regulatory DNA, a process called …