Malignant tumors seriously endanger human health and life, and restrict economic
development. Human leukocyte antigen (HLA) is the expression product of the human major …

Simple Summary Acute myeloid leukemia is a rare blood cancer that develops from the
clonal expansion of malignant myeloid precursor cells located in the bone marrow. Despite …

Idiopathic aplastic anemia (IAA) pathophysiology is dominated by autoreactivity of human
leukocyte antigen (HLA)-restricted T-cells against antigens presented by hematopoietic stem …

Abstract Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of
allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia …

Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors
have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as …

We analyzed the association between HLA polymorphisms and susceptibility to SARS‐CoV‐
2 infection and disease severity. Genotyping data from a total of 9373 COVID‐19‐positive …

Background Osteosarcoma is one of the most prevalent bone malignancies with a poor
prognosis. The N7-methylguanosine (m7G) modification facilitates the modification of RNA …

Clonal evolution to secondary paroxysmal nocturnal hemoglobinuria (PNH) or myeloid
neoplasia (MN) represents one of the long-term complications of patients with aplastic …

PURPOSE Using a real-world database with matched genomic-transcriptomic molecular
data, we sought to characterize the distinct molecular correlates underlying clinical …

Clonal hematopoiesis (CH) is a result of the selective expansion of hematopoietic stem and
progenitor cells (HSPCs) carrying somatic mutations originating from a primary HSC. The …