Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Novel methods for multi-ancestry polygenic prediction and their evaluations in 5.1 million individuals of diverse ancestry
Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …
suboptimal performance in non-European ancestry populations raises questions about their …
Exploring the role of underrepresented populations in polygenic risk scores for neurodegenerative disease risk prediction
K Step, CAA Ndong Sima, I Mata… - Frontiers in Neuroscience, 2024 - frontiersin.org
Neurodegenerative diseases (NDs) are characterized by the progressive loss of neuronal
function and structure (Lamptey et al., 2022). Additionally, neurodegeneration is associated …
function and structure (Lamptey et al., 2022). Additionally, neurodegeneration is associated …
Trans-ancestry polygenic models for the prediction of LDL blood levels: an analysis of the United Kingdom Biobank and Taiwan Biobank
Polygenic risk score (PRS) predictions often show bias toward the population of available
genome-wide association studies (GWASs), which is typically of European ancestry. This …
genome-wide association studies (GWASs), which is typically of European ancestry. This …
Genetic risk for hospitalization of African American patients with severe mental illness reveals HLA loci
Background Mood disorders such as major depressive and bipolar disorders, along with
posttraumatic stress disorder (PTSD), schizophrenia (SCZ), and other psychotic disorders …
posttraumatic stress disorder (PTSD), schizophrenia (SCZ), and other psychotic disorders …
[HTML][HTML] Leveraging genetic correlations and multiple populations to improve genetic risk prediction for non-European populations
The disparity in genetic risk prediction accuracy between European and non-European
individuals highlights a critical challenge in health inequality. To bridge this gap, we …
individuals highlights a critical challenge in health inequality. To bridge this gap, we …
[引用][C] Transferability of polygenic risk score among diverse ancestries
X Cheng, S Zhao - Clinical and Translational Discovery, 2023 - Wiley Online Library
Polygenic risk score (PRS) has recently emerged as a powerful tool for predicting the risk of
complex traits by summarizing weighted single nucleotide polymorphisms (SNPs) …
complex traits by summarizing weighted single nucleotide polymorphisms (SNPs) …