Current strategies of antiviral drug discovery for COVID-19

M Mei, X Tan - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
SARS-CoV-2 belongs to the family of enveloped, single-strand RNA viruses known as
Betacoronavirus in Coronaviridae, first reported late 2019 in China. It has since been …

Isatin derivatives as broad-spectrum antiviral agents: the current landscape

T Elsaman, MS Mohamed, EM Eltayib… - Medicinal Chemistry …, 2022 - Springer
In recent decades, several viruses have resulted in large outbreaks with serious health,
economic and social consequences. The current unprecedented outbreak of the new …

[HTML][HTML] Non-steroidal anti-inflammatory drugs in the era of the Covid-19 pandemic in the context of the human and the environment

D Wojcieszyńska, H Guzik, U Guzik - Science of the Total Environment, 2022 - Elsevier
From 2019, life in the world has mainly been determined by successive waves of the COVID-
19 epidemic. During this time, the virus structure, action, short-and long-term effects of the …

SARS-CoV-2 seroprevalence structure of the russian population during the COVID-19 pandemic

AY Popova, VS Smirnov, EE Andreeva, EA Babura… - Viruses, 2021 - mdpi.com
The SARS-CoV-2 pandemic, which came to Russia in March 2020, is accompanied by
morbidity level changes and can be tracked using serological monitoring of a representative …

Anti-SARS-CoV-2 strategies and the potential role of miRNA in the assessment of COVID-19 morbidity, recurrence, and therapy

M Narożna, B Rubiś - International Journal of Molecular Sciences, 2021 - mdpi.com
Recently, we have experienced a serious pandemic. Despite significant technological
advances in molecular technologies, it is very challenging to slow down the infection spread …

Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation

A Serra, M Fratello, A Federico, R Ojha… - Briefings in …, 2022 - academic.oup.com
The pharmacological arsenal against the COVID-19 pandemic is largely based on generic
anti-inflammatory strategies or poorly scalable solutions. Moreover, as the ongoing …

Therapeutic and anti-inflammatory effects of baricitinib on mortality, ICU transfer, clinical improvement, and CRS-related laboratory parameters of hospitalized patients …

S Tahsini Tekantapeh, M Ghojazadeh… - Expert Review of …, 2022 - Taylor & Francis
Background Due to the high incidence and mortality of the worldwide COVID-19 pandemic,
beneficial effects of effective antiviral and anti-inflammatory drugs used in other diseases …

Current advancements and future prospects of COVID-19 vaccines and therapeutics: a narrative review

A Sanyaolu, C Okorie, A Marinkovic… - … in vaccines and …, 2022 - journals.sagepub.com
Coronavirus disease 2019 (COVID-19) has made a global impact on the daily lives of
humanity, devastating health systems, and cataclysmically affecting the world's economy …

Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19

E Zendedel, L Tayebi, M Nikbakht… - Current Stem Cell …, 2024 - ingentaconnect.com
Mesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral
disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration …

A case-control of patients with COVID-19 to explore the association of previous hospitalisation use of medication on the mortality of COVID-19 disease: a propensity …

J Monserrat Villatoro, G Mejia-Abril, L Diaz Garcia… - Pharmaceuticals, 2022 - mdpi.com
Data from several cohorts of coronavirus disease 2019 (COVID-19) suggest that the most
common comorbidities for severe COVID-19 disease are the elderly, high blood pressure …