It is now plausible to dock libraries of 10 million molecules against targets over several days
or weeks. When the molecules screened are commercially available, they may be rapidly …

Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

Recently, a novel coronavirus, known as severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has raised global concerns, being the etiological agent of the current …

In continuation of our previous studies, we developed polymeric epigallocatechin 3-gallate
(EGCG)-loaded nanoparticles (NPs) coupled with folic acid (FA), able to dually bind the …

Abstract PARP-1, a nuclear protein, is one of the key member of the DNA repair assembly
and thereby emerged as an attractive target in anti-cancer drug discovery. PARP-1 plays a …

Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

The influenza pandemic is a major threat to human health, and highly aggressive strains
such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to …

Based on the fact that a search for influenza antivirals among nucleoside analogues has
drawn very little attention of chemists, the present study reports the synthesis of a series of 1 …

Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which
seriously threatens global human health and causes substantial economic losses every …

Influenza virus PA endonuclease has recently emerged as an attractive target for the
development of novel antiviral therapeutics. This is an enzyme with divalent metal ion …