[HTML][HTML] To re-examine the intersection of microglial activation and neuroinflammation in neurodegenerative diseases from the perspective of pyroptosis

Y Li, YJ Li, ZQ Zhu - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, and motor neuron disease, are diseases characterized by neuronal …

[HTML][HTML] Hypoxia and the endometrium: An indispensable role for HIF-1α as therapeutic strategies

W Dai, R Guo, X Na, S Jiang, J Liang, C Guo, Y Fang… - Redox Biology, 2024 - Elsevier
Hypoxia-inducible factor 1 alpha (HIF-1α) is a major molecular mediator of the hypoxic
response. In the endometrium, local hypoxic conditions induced by hormonal fluctuations …

Oleuropein attenuates the nephrotoxic effect of sunitinib in rats: Unraveling the potential role of SIRT6/Notch-1/NLRP-3/IL-1β axis

RA Elrashidy, HE Mohamed, SMA Aal… - Archives of Biochemistry …, 2024 - Elsevier
Sunitinib (SUN) is a chemotherapeutic agent clinically approved for treatment of metastatic
renal carcinoma. Despite its remarkable benefits, various renal toxicities have been reported …

Lack of annexin a1 exacerbates inflammatory response in acute endometritis model

RR Vieira, RA da Silva, GRS Sasso, PC Franco… - Inflammation, 2024 - Springer
Abstract Annexin A1 (AnxA1) is a glucocorticoid-inducible protein and an important
endogenous modulator of inflammation. However, its effect in the endometrial …

[HTML][HTML] PI3K/AKT signaling pathway associates with pyroptosis and inflammation in patients with endometriosis

M An, X Fu, X Meng, H Liu, Y Ma, Y Li, Q Li… - Journal of Reproductive …, 2024 - Elsevier
Endometriosis (EMS) is known to be closely associated with inflammation. We evaluate the
possible mechanism linking the PI3K/AKT signaling pathway with pyroptosis and …

The marine Penicillium sp. GGF16-1-2 metabolite dicitrinone G inhibits pancreatic angiogenesis by regulating the activation of NLRP3 inflammasome

Z Shi, M Zhang, H Fan, Y Chen, S Dong, F Zhou… - Journal of Natural …, 2024 - Springer
Citrinin derivatives have been found to have various pharmacological activities, such as anti-
inflammatory, anti-tumor, and antioxidant effects. Dicitrinone G (DG) was a new citrinin dimer …

[HTML][HTML] Role of the NLRP3 inflammasome in gynecological disease

X Zheng, D Zhao, Y Jin, Y Liu, D Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the innate
immune system and is a three-part macromolecular complex comprising the NLRP3 protein …

Progesterone resistance in endometriosis: A pathophysiological perspective and potential treatment alternatives

HC Tang, TC Lin, MH Wu… - Reproductive Medicine and …, 2024 - Wiley Online Library
Background Endometriosis is a common gynecological disease affecting women of
reproductive age. Patients with endometriosis frequently experience severe chronic pain …

[HTML][HTML] Activation of the Macrophage-Associated Inflammasome Exacerbates Myocardial Fibrosis Through the 15-HETE-Mediated Pathway in Acute Myocardial …

X Chen, Z Du, D Guo, J Guo, Q Sun, T Liu, K Hua, C Li… - Engineering, 2024 - Elsevier
This investigation elucidates the spatiotemporal dynamics of NOD-like receptor family pyrin
domain containing 3 (NLRP3) inflammasome activation following myocardial infarction (MI) …

[HTML][HTML] Regulated Cell Death in Endometriosis

E Huang, X Wang, L Chen - Biomolecules, 2024 - mdpi.com
Regulated cell death (RCD) represents a distinct mode of cell demise, differing from
accidental cell death (ACD), characterized by specific signaling cascades orchestrated by …