Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral drugs
categorized into 13 functional groups have been formally approved for the treatment of the …

The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …

Background The HIV pandemic is characterized by extensive genetic variability, which has
challenged the development of HIV drugs and vaccines. Although HIV genomes have been …

Despite the active development of SARS-CoV-2 surveillance methods (eg, Nextstrain,
GISAID, Pangolin), the global emergence of various SARS-CoV-2 viral lineages that …

Amino acid mutations in proteins are random and those mutations which are beneficial or
neutral survive during the course of evolution. Conservation or co-evolution analyses are …

The HIV-1 Env spike is the main protein complex that facilitates HIV-1 entry into CD4+ host
cells. HIV-1 entry is a multistep process that is not yet completely understood. This process …

Adeno-associated virus (AAV) is a promising gene therapy vector because of its efficient
gene delivery and relatively mild immunogenicity. To improve delivery target specificity …

Despite the active development of SARS-CoV-2 surveillance methods (eg, Nextstrain,
GISAID, Pangolin), the global emergence of various SARS-CoV-2 viral lineages that …

For decades, immunologists and virologists have worked somewhat independently trying to
understand AIDS disease progression for the benefit of improved patient care. Their efforts …

Die derzeitigen Leitlinien zur antiretroviralen Therapie von HIV Patienten empfehlen die
Integrase-Inhibitoren als potente Kombinationspartner mit einer breiten Wirksamkeit gegen …