Ferritinophagy activation and sideroflexin1-dependent mitochondrial iron overload contribute to patulin-induced cardiac inflammation and fibrosis

WC Sun, NN Wang, R Li, XC Sun, JW Liao… - Science of The Total …, 2023 - Elsevier
Patulin (PAT) is a mycotoxin that is commonly present throughout the ecosystem where fungi
grow and mainly contaminates food, soil, and water. PAT was found to be cardiotoxic in …

Melatonin: A potential protective multifaceted force for sepsis-induced cardiomyopathy

E Casper, L El Wakeel, N Sabri, R Khorshid, SF Fahmy - Life Sciences, 2024 - Elsevier
Sepsis is a life-threatening condition manifested by organ dysfunction caused by a
dysregulated host response to infection. Lung, brain, liver, kidney, and heart are among the …

An overview of the mechanisms and potential roles of extracellular vesicles in septic shock

M Cao, M Shi, B Zhou, H Jiang - Frontiers in Immunology, 2024 - frontiersin.org
Septic shock, a subset of sepsis, is a fatal condition associated with high morbidity and
mortality. However, the pathophysiology of septic shock is not fully understood. Moreover …

[HTML][HTML] Canonical transient receptor potential channel 1 aggravates myocardial ischemia-and-reperfusion injury by upregulating reactive oxygen species

HN Zhang, M Zhang, W Tian, W Quan, F Song… - Journal of …, 2023 - Elsevier
The canonical transient receptor potential channel (TRPC) proteins form Ca 2+-permeable
cation channels that are involved in various heart diseases. However, the roles of specific …

Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling …

H Zhao, P Wang, X Wang, W Du, HH Yang… - Cardiovascular …, 2023 - academic.oup.com
Aims Systemic inflammation occurs commonly during many human disease settings and
increases vascular permeability, leading to organ failure, and lethal outcomes. Lipocalin 10 …

[HTML][HTML] The DNA-dependent protein kinase catalytic subunit exacerbates endotoxemia-induced myocardial microvascular injury by disrupting the MOTS-c/JNK …

R Zou, W Shi, X Chang, M Zhang, S Tan, R Li… - Theranostics, 2024 - ncbi.nlm.nih.gov
Rationale: The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) promotes
pathological mitochondrial fission during septic acute kidney injury. The mitochondrial open …

CEBPD regulates oxidative stress and inflammatory responses in hypertensive cardiac remodeling

J Zhao, J Hu, R Zhang, J Deng - Shock, 2023 - journals.lww.com
Hypertension seems to inevitably cause cardiac remodeling, increasing the mortality of
patients. This study aimed to explore the molecular mechanism of CCAAT/enhancer-binding …

DNA-PKcs phosphorylates cofilin2 to induce endothelial dysfunction and microcirculatory disorder in endotoxemic cardiomyopathy

Y Du, P Zhu, Y Li, J Yu, T Xia, X Chang, H Zhu, R Li… - Research, 2024 - spj.science.org
The presence of endotoxemia is strongly linked to the development of endothelial
dysfunction and disruption of myocardial microvascular reactivity. These factors play a …

[HTML][HTML] Larixyl acetate, a TRPC6 inhibitor, attenuates pressure overload‑induced heart failure in mice

M Jia, W Liu, K Zhang, Z Wang… - Molecular …, 2024 - … .spandidos-publications.com
Heart failure is a primary cause of global mortality. In the present study, whether larixyl
acetate, an inhibitor of transient receptor potential cation channel subfamily C member 6 …

Integrated mRNA and miRNA analysis reveals the regulatory network of oxidative stress and inflammation in Coilia nasus brains during air exposure and salinity …

J Gao, Q Mang, Y Liu, Y Sun, G Xu - BMC genomics, 2024 - Springer
Background Air exposure is an inevitable source of stress that leads to significant mortality in
Coilia nasus. Our previous research demonstrated that adding 10‰ NaCl to aquatic water …