Anaemia and malaria

NJ White - Malaria journal, 2018 - Springer
Malaria is a major cause of anaemia in tropical areas. Malaria infection causes haemolysis
of infected and uninfected erythrocytes and bone marrow dyserythropoiesis which …

The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

J Beld, EC Sonnenschein, CR Vickery, JP Noel… - Natural product …, 2014 - pubs.rsc.org
Covering: up to 2013 Although holo-acyl carrier protein synthase, AcpS, a
phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until …

The potential for microalgae as bioreactors to produce pharmaceuticals

N Yan, C Fan, Y Chen, Z Hu - International journal of molecular sciences, 2016 - mdpi.com
As photosynthetic organisms, microalgae can efficiently convert solar energy into biomass.
Microalgae are currently used as an important source of valuable natural biologically active …

Photosynthetic biomanufacturing in green algae; production of recombinant proteins for industrial, nutritional, and medical uses

BA Rasala, SP Mayfield - Photosynthesis research, 2015 - Springer
Recombinant proteins are widely used for industrial, nutritional, and medical applications.
Green microalgae have attracted considerable attention recently as a biomanufacturing …

Transgene expression in microalgae—from tools to applications

L Doron, N Segal, M Shapira - Frontiers in plant science, 2016 - frontiersin.org
Microalgae comprise a biodiverse group of photosynthetic organisms that reside in water
sources and sediments. The green microalgae Chlamydomonas reinhardtii was adopted as …

Chlamydomonas reinhardtii: A Factory of Nutraceutical and Food Supplements for Human Health

A Masi, F Leonelli, V Scognamiglio, G Gasperuzzo… - Molecules, 2023 - mdpi.com
Chlamydomonas reinhardtii (C. reinhardtii) is one of the most well-studied microalgae
organisms that revealed important information for the photosynthetic and metabolic …

Microalgae and cyanobacteria as enzyme biofactories

BSAF Brasil, FG de Siqueira, TFC Salum, CM Zanette… - Algal research, 2017 - Elsevier
Microalgae consist of a diverse group that includes prokaryotic cyanobacteria and
eukaryotic photosynthetic microorganisms that inhabit freshwater and marine habitats …

The algal chloroplast as a synthetic biology platform for production of therapeutic proteins

YM Dyo, S Purton - Microbiology, 2018 - microbiologyresearch.org
The chloroplast of Chlamydomonas reinhardtii and other microalgae represents an attractive
new platform for the synthesis of recombinant therapeutics using synthetic biology (synbio) …

A malaria vaccine adjuvant based on recombinant antigen binding to liposomes

WC Huang, B Deng, C Lin, KA Carter, J Geng… - Nature …, 2018 - nature.com
Pfs25 is a malaria transmission-blocking vaccine antigen candidate, but its apparently
limited immunogenicity in humans has hindered clinical development. Here, we show that …

Production of unique immunotoxin cancer therapeutics in algal chloroplasts

M Tran, C Van, DJ Barrera… - Proceedings of the …, 2013 - National Acad Sciences
The idea of targeted therapy, whereby drug or protein molecules are delivered to specific
cells, is a compelling approach to treating disease. Immunotoxins are one such targeted …