Development of a multiomics model for identification of predictive biomarkers for COVID-19 severity: a retrospective cohort study

SK Byeon, AK Madugundu, K Garapati… - The Lancet Digital …, 2022 - thelancet.com
Background COVID-19 is a multi-system disorder with high variability in clinical outcomes
among patients who are admitted to hospital. Although some cytokines such as interleukin …

Role of E3 ubiquitin ligases and deubiquitinating enzymes in SARS-CoV-2 infection

M Zhao, M Zhang, Z Yang, Z Zhou, J Huang… - Frontiers in Cellular …, 2023 - frontiersin.org
Ever since its emergence in 2019, COVID-19 has rapidly disseminated worldwide,
engendering a pervasive pandemic that has profoundly impacted healthcare systems and …

SARS-CoV-2 and UPS with potentials for therapeutic interventions

J Ferdoush, RA Kadir, SS Kaplanoglu, M Osborn - Gene, 2024 - Elsevier
The Ubiquitin proteasome system (UPS), an essential eukaryotic/host/cellular post-
translational modification (PTM), plays a critical role in the regulation of diverse cellular …

Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals

EJ Fritch, AL Mordant, TSK Gilbert… - Journal of Proteome …, 2023 - ACS Publications
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress
response to viral infection, and inflammation. Previous work has demonstrated that …

Automated sample preparation workflow for tandem mass tag-based proteomics

DG Mun, NS Joshi, R Budhraja… - Journal of the …, 2023 - ACS Publications
Although tandem mass tag (TMT)-based isobaric labeling has become a powerful approach
for multiplexed protein quantitation, automating the workflow for this technique has not been …

Leishmania infection upregulates and engages host macrophage Argonaute 1, and system-wide proteomics reveals Argonaute 1-dependent host response

A Moradimotlagh, S Chen, S Koohbor… - Frontiers in …, 2023 - frontiersin.org
Leishmania donovani, an intracellular protozoan parasite, is the causative agent of visceral
leishmaniasis, the most severe form of leishmaniasis in humans. It is becoming increasingly …

Mass spectrometry‐based proteomic profiling of sonicate fluid differentiates Staphylococcus aureus periprosthetic joint infection from non‐infectious failure: A pilot …

CR Fisher, KK Mangalaparthi… - PROTEOMICS …, 2023 - Wiley Online Library
Purpose This pilot study aimed to use proteomic profiling of sonicate fluid samples to
compare host response during Staphylococcus aureus‐associated periprosthetic joint …

An explainable model of host genetic interactions linked to COVID-19 severity

A Onoja, N Picchiotti, C Fallerini, M Baldassarri… - Communications …, 2022 - nature.com
We employed a multifaceted computational strategy to identify the genetic factors
contributing to increased risk of severe COVID-19 infection from a Whole Exome …

Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration

E Gavilán, R Medina-Guzman… - Cells, 2024 - mdpi.com
The COVID-19 pandemic has brought to the forefront the intricate relationship between
SARS-CoV-2 and its impact on neurological complications, including potential links to …

COVIDpro: Database for mining protein dysregulation in patients with COVID-19

F Zhang, A Luna, T Tan, Y Chen… - Journal of Proteome …, 2023 - ACS Publications
The ongoing pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 still has limited treatment options. Our …