Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases

SC Liew, ED Gupta - European journal of medical genetics, 2015 - Elsevier
Abstract The Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is
associated with various diseases (vascular, cancers, neurology, diabetes, psoriasis, etc) …

Homocysteine and MTHFR mutations: relation to thrombosis and coronary artery disease

EA Varga, AC Sturm, CP Misita, S Moll - Circulation, 2005 - Am Heart Assoc
e289 preparations are needed before blood testing. Occasionally, a practitioner may order a
fasting homocysteine level, which requires fasting for 10 hours before the blood draw …

[HTML][HTML] Homocysteine, MTHFR and risk of venous thrombosis: a meta‐analysis of published epidemiological studies

M Den Heijer, S Lewington, R Clarke - Journal of Thrombosis and …, 2005 - Elsevier
Context: It has been suggested that elevated total plasma homocysteine levels are
associated with the risk of venous thrombosis. Objective: To assess the relationship of …

The genetics of venous thromboembolism

R Gohil, G Peck, P Sharma - Thrombosis and haemostasis, 2009 - thieme-connect.com
We conducted a systematic and comprehensive meta-analysis on all candidate genes to
assess their genetic contribution to the aetiology of venous thromboembolism …

[图书][B] Folate in health and disease

LB Bailey - 2009 - taylorfrancis.com
During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations

TA Trikalinos, G Salanti, MJ Khoury… - American journal of …, 2006 - academic.oup.com
The authors evaluated whether statistically significant violations of Hardy-Weinberg
equilibrium (HWE) or the magnitude of deviations from HWE may contribute to the problem …

No association between the common MTHFR 677C→ T polymorphism and venous thrombosis: results from the MEGA study

ID Bezemer, CJM Doggen, HL Vos… - Archives of internal …, 2007 - jamanetwork.com
Background Increased homocysteine levels are related to the occurrence of venous
thrombosis, but whether this relation is causal is unclear. The T-variant of the common …

[PDF][PDF] Hypercoagulable states: an algorithmic approach to laboratory testing and update on monitoring of direct oral anticoagulants

MO Nakashima, HJ Rogers - Blood research, 2014 - synapse.koreamed.org
Hypercoagulability can result from a variety of inherited and, more commonly, acquired
conditions. Testing for the underlying cause of thrombosis in a patient is complicated both by …

Rare variants in MTHFR predispose to occurrence and recurrence of pulmonary embolism

JS Tan, XX Yan, Y Wu, X Gao, XQ Xu, X Jiang… - International Journal of …, 2021 - Elsevier
Background Rare genetic variants play a critical role in unprovoked pulmonary embolism
(PE). However, the known risk genes only account a small proportion of patients with PE …

the aetiology of primary Budd–Chiari syndrome–differences between the West and China

X Qi, G Han, X Guo, V De Stefano, K Xu… - Alimentary …, 2016 - Wiley Online Library
Background China may have the largest number of Budd–Chiari syndrome (BCS) cases in
the world (at least 1914 original papers were published, and at least 20 191 BCS patients …