Crohn's disease is an inflammatory bowel disease that is characterized by chronic
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …

Probiotics have been considered as an economical and safe alternative for the treatment of
a large number of chronic diseases and improvement of human health. They are known to …

The tumor microenvironment (TME) is connected to immunotherapy responses, but it
remains unclear how cancer cells and host tissues differentially influence the immune …

Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Host-microbial cross-talk plays a crucial role in maintenance of gut homeostasis. However,
how microbiota-derived metabolites, eg, butyrate, regulate functions of neutrophils in the …

Intestinal immune homeostasis and microbiome structure play a critical role in the
pathogenesis and progress of inflammatory bowel disease (IBD), whereas IBD treatment …

Host microbial cross-talk is essential to maintain intestinal homeostasis. However,
maladaptation of this response through microbial dysbiosis or defective host defense toward …

Group 3 innate lymphoid cells (ILC3s) regulate immunity and inflammation, yet their role in
cancer remains elusive. Here, we identify that colorectal cancer (CRC) manifests with …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …