Mitochondria play a central role in cellular energy provision. The organelles contain their
own genome with a modified genetic code. The mammalian mitochondrial genome is …

Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

The discovery that mutations in mitochondrial DNA (mtDNA) can be pathogenic in humans
has increased interest in understanding mtDNA maintenance. The functional state of mtDNA …

Fifty years ago it was reported that baker's yeast, Saccharomyces cerevisiae, can form
“petite colonie” mutants when treated with the DNA-targeting drug acriflavin. To mark the …

RNase mitochondrial RNA processing (RNase MRP) mutants have been shown to have an
exit-from-mitosis defect that is caused by an increase in CLB2 mRNA levels, leading to …

RNase P and RNase mitochondrial RNA processing (MRP) are ribonucleoproteins (RNPs)
that consist of a catalytic RNA and a varying number of protein cofactors. RNase P is …

The great amount of molecular information and the many molecular genetic techniques
available make Schizosaccharomyces pombe an ideal model eukaryote, complementary to …

We have identified a cell cycle delay in Saccharomyces cerevisiae RNase MRP mutants.
Mutants delay with large budded cells, dumbbell-shaped nuclei, and extended spindles …

The fission yeast Schizosaccharomyces pombe, widely used for studies of cell cycle control
and differentiation, provides an alternative and complementary model to the budding yeast …

Publisher Summary This chapter discusses mitochondrial DNA (mtDNA) structures and its
functions. The human mtDNA is representative of mammalian mitochondrial genomes …