Abstract Lipocalin-2 (LCN-2) is a novel, 198 amino acid adipocytokine also referred to as
neutrophil gelatinase-associated lipocalin (NGAL). LCN-2 is a circulatory protein …

Progress has been made in our understanding of the mechanisms of endoplasmic reticulum
(ER) proteostasis, ER stress and the unfolded protein response (UPR), as well as ER stress …

Eukaryotic cells contain an elegant protein quality control system that is crucial in
maintaining cellular homeostasis; however, dysfunction of this system results in …

Reactive astrocytes (RA) secrete lipocalin-2 (LCN2) glycoprotein that regulates diverse
cellular processes including cell death/survival, inflammation, iron delivery and cell …

Cancer vaccines are viewed as a promising immunotherapy to eradicate malignant tumors
and aim to elicit the patients' own tumor-specific immune response against tumor cells …

Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

Lipocalin 2 (Lcn2), an innate immune protein, has emerged as a critical iron regulatory
protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 …

Albuminuria is a hallmark of glomerular disease of various etiologies. It is not only a
symptom of glomerular disease but also a cause leading to glomerulosclerosis, interstitial …

Autophagy is a cellular homeostatic program for the turnover of cellular organelles and
proteins, in which double-membraned vesicles (autophagosomes) sequester cytoplasmic …

Obstructive nephropathy favors the progression to chronic kidney disease (CKD), a severe
health problem worldwide. The unilateral ureteral obstruction (UUO) model is used to study …