For an increasing number of preclinical samples, both detailed molecular profiles and their
responses to various drugs are becoming available. Efforts to understand, and predict, drug …

Oncolytic viruses (OVs) can selectively kill tumor cells without affecting normal cells, as well
as activate the innate and adaptive immune systems in patients. Thus, they have been …

Drug repositioning is an efficient and promising strategy for traditional drug discovery and
development. Many research efforts are focused on utilizing deep-learning approaches …

In recent years, with the rapid development of wind and solar power generation, some
problems arise gradually and are often inherent to intermittency. Currently, one of the …

Motivation Tumor mutational burden (TMB) is an indicator of the efficacy and prognosis of
immune checkpoint therapy in colorectal cancer (CRC). In general, patients with higher TMB …

Breast cancer patients often have recurrence and metastasis after surgery. Predicting the
risk of recurrence and metastasis for a breast cancer patient is essential for the development …

Drug repositioning is a new way of applying the existing therapeutics to new disease
indications. Due to the exorbitant cost and high failure rate in developing new drugs, the …

Background Non-small cell lung cancer (NSCLC) is one of the most prevalent causes of
cancer-related death worldwide. Recently, there are many important medical advancements …

Despite recent improvements in treatment modalities, pancreatic cancer remains a highly
lethal tumor with mortality rate increasing every year. Poly (ADP-ribose) polymerase (PARP) …

The identification of disease-causing genes is critical for mechanistic understanding of
disease etiology and clinical manipulation in disease prevention and treatment. Yet the …