The P2X7 receptor
R Sluyter - Protein Reviews: Volume 19, 2017 - Springer
The P2X7 receptor is a trimeric ion channel gated by extracellular adenosine 5′-
triphosphate. The receptor is present on an increasing number of different cells types …
triphosphate. The receptor is present on an increasing number of different cells types …
Pathophysiological role of purines and pyrimidines in neurodevelopment: unveiling new pharmacological approaches to congenital brain diseases
M Fumagalli, D Lecca, MP Abbracchio… - Frontiers in …, 2017 - frontiersin.org
In recent years, a substantial body of evidence has emerged demonstrating that purine and
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …
pyrimidine synthesis and metabolism play major roles in controlling embryonic and fetal …
P2X7 as a scavenger receptor for innate phagocytosis in the brain
BJ Gu, JS Wiley - British Journal of Pharmacology, 2018 - Wiley Online Library
The P2X7 receptor has been widely studied for its ATP‐induced pro‐inflammatory effect, but
in the absence of a ligand, P2X7 has a second function as a scavenger receptor, which is …
in the absence of a ligand, P2X7 has a second function as a scavenger receptor, which is …
P2X7 receptors regulate phagocytosis and proliferation in adult hippocampal and SVZ neural progenitor cells: implications for inflammation in neurogenesis
Identifying the signaling mechanisms that regulate adult neurogenesis is essential to
understanding how the brain may respond to neuro-inflammatory events. P2X7 receptors …
understanding how the brain may respond to neuro-inflammatory events. P2X7 receptors …
P2X7 receptor signaling during adult hippocampal neurogenesis
Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus.
Granular neurons generated from resident pools of stem or progenitor cells provide a …
Granular neurons generated from resident pools of stem or progenitor cells provide a …
Purinergic P2X7 Receptor: A Therapeutic Target in Amyotrophic Lateral Sclerosis
ADJ Mckenzie, TR Garrett, EL Werry… - ACS Chemical …, 2022 - ACS Publications
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by upper and lower motor neuron loss. The pathomechanisms of ALS are still …
characterized by upper and lower motor neuron loss. The pathomechanisms of ALS are still …
P2X7 from j774 murine macrophages acts as a scavenger receptor for bacteria but not yeast
G Pérez-Flores, C Hernández-Silva… - Biochemical and …, 2016 - Elsevier
We studied the effects of extracellular ATP and Ca 2+ on uptake of bacteria (Staphylococcus
aureus or Escherichia coli) and live yeast (Candida glabrata) by J774 macrophages to …
aureus or Escherichia coli) and live yeast (Candida glabrata) by J774 macrophages to …
[PDF][PDF] In vitro produced neuronal network studies on the role of P2X7 receptor and its relevance to alzheimer's disease
L Francistiová - 2022 - phd.mater.uni-mate.hu
Neuroinflammation is one of the major underlying pathologies of many neurodegenerative
diseases, including Alzheimer's disease (AD). It results from various effects such as tissue …
diseases, including Alzheimer's disease (AD). It results from various effects such as tissue …
P2X7 受体调节成人海马神经发生
HC Leeson, T Chan-Ling, MD Lovelace… - 中国神经再生研究 …, 2019 - sjzsyj.com.cn
orcid: 0000-0002-4694-8513 (Hannah C. Leeson) 0000-0002-8225-3671 (Tailoi Chan-Ling)
0000-0003-2066-3031 (Michael D. Lovelace) 0000-0003-0161-2204 (Jeremy C. Brownlie) …
0000-0003-2066-3031 (Michael D. Lovelace) 0000-0003-0161-2204 (Jeremy C. Brownlie) …