Development of the mammalian kidney
AP McMahon - Current topics in developmental biology, 2016 - Elsevier
The basic unit of kidney function is the nephron. In the mouse, around 14,000 nephrons form
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
in a 10-day period extending into early neonatal life, while the human fetus forms the adult …
[HTML][HTML] Pericytes, an overlooked player in vascular pathobiology
D Ferland-McCollough, S Slater, J Richard… - Pharmacology & …, 2017 - Elsevier
Pericytes are a heterogeneous population of cells located in the blood vessel wall. They
were first identified in the 19th century by Rouget, however their biological role and potential …
were first identified in the 19th century by Rouget, however their biological role and potential …
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis
The human kidney contains up to 2 million epithelial nephrons responsible for blood
filtration. Regenerating the kidney requires the induction of the more than 20 distinct cell …
filtration. Regenerating the kidney requires the induction of the more than 20 distinct cell …
Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network
Human pluripotent stem cell-derived kidney organoids recapitulate developmental
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
processes and tissue architecture, but intrinsic limitations, such as lack of vasculature and …
Single-cell RNA sequencing of human kidney
J Liao, Z Yu, Y Chen, M Bao, C Zou, H Zhang, D Liu… - Scientific data, 2020 - nature.com
A comprehensive cellular anatomy of normal human kidney is crucial to address the cellular
origins of renal disease and renal cancer. Some kidney diseases may be cell type-specific …
origins of renal disease and renal cancer. Some kidney diseases may be cell type-specific …
Evaluation of variability in human kidney organoids
The utility of human pluripotent stem cell–derived kidney organoids relies implicitly on the
robustness and transferability of the protocol. Here we analyze the sources of transcriptional …
robustness and transferability of the protocol. Here we analyze the sources of transcriptional …
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
Human induced pluripotent stem cell–derived podocytes mature into vascularized glomeruli upon experimental transplantation
Glomerular podocytes express proteins, such as nephrin, that constitute the slit diaphragm,
thereby contributing to the filtration process in the kidney. Glomerular development has been …
thereby contributing to the filtration process in the kidney. Glomerular development has been …
[HTML][HTML] Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development
The current understanding of mammalian kidney development is largely based on mouse
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …
models. Recent landmark studies revealed pervasive differences in renal embryogenesis …
Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis
A Kobayashi, JW Mugford, AM Krautzberger, N Naiman… - Stem cell reports, 2014 - cell.com
The mammalian kidney is a complex organ consisting of multiple cell types. We previously
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …