Heart failure is a clinical syndrome where cardiac output is not sufficient to sustain adequate
perfusion and normal bodily functions, initially during exercise and in more severe forms …

Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy world-wide,
affecting approximately 1 in 500 individuals. Current therapeutic interventions comprise …

Background The relationship between exercise hemodynamics, loading conditions, and
medical treatment in patients with obstructive hypertrophic cardiomyopathy (HCM) is …

Vertebrates developed pulmonary circulation and septated the heart into venous and arterial
compartments, as the adaptation from aquatic to terrestrial life requires more oxygen and …

The development of gene-editing technology has been one of the biggest advances in
biomedicine over the past two decades. Not only can it be used as a research tool to build a …

Studies over the last 30 years have identified hypertrophic cardiomyopathy (HCM) as
predominantly an autosomal dominant disorder caused by disease-causing variants in …

Alcohol septal ablation (ASA) is a well-established procedure for septal reduction therapy in
patients with obstructive hypertrophic cardiomyopathy, significant at rest or provocable …

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common heritable heart disease.
Although HCM has been reported to be associated with many variants of genes involved in …

Background Hypertrophic cardiomyopathy (HCM) is a common cardiac genetic disorder that
clinically manifests with sudden death and progressive heart failure. Moreover, thyroid …

Hypertrophic cardiomyopathy (HCM) patients often present an enhanced arrhythmogenicity
that can lead to lethal arrhythmias, especially during exercise. Recent studies have …