Anti-tuberculosis treatment strategies and drug development: challenges and priorities

VA Dartois, EJ Rubin - Nature Reviews Microbiology, 2022 - nature.com
Despite two decades of intensified research to understand and cure tuberculosis disease,
biological uncertainties remain and hamper progress. However, owing to collaborative …

Antimicrobial resistance in ESKAPE pathogens

DMP De Oliveira, BM Forde, TJ Kidd… - Clinical microbiology …, 2020 - Am Soc Microbiol
Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Infection microenvironment-related antibacterial nanotherapeutic strategies

Z Wang, X Liu, Y Duan, Y Huang - Biomaterials, 2022 - Elsevier
The emergence and spread of antibiotic resistance is one of the biggest challenges in public
health. There is an urgent need to discover novel agents against the occurrence of multidrug …

Synergistic effects between metal nanoparticles and commercial antimicrobial agents: A review

AI Ribeiro, AM Dias, A Zille - ACS Applied Nano Materials, 2022 - ACS Publications
Nanotechnology has expanded into a broad range of clinical applications. In particular,
metal nanoparticles (MNPs) display unique antimicrobial properties, a fundamental function …

[HTML][HTML] The spread of antibiotic resistance to humans and potential protection strategies

D Ding, B Wang, X Zhang, J Zhang, H Zhang… - Ecotoxicology and …, 2023 - Elsevier
Antibiotic resistance is currently one of the greatest threats to human health. Widespread
use and residues of antibiotics in humans, animals, and the environment can exert selective …

Caffeic acid and its derivatives: antimicrobial drugs toward microbial pathogens

F Khan, NI Bamunuarachchi… - Journal of agricultural …, 2021 - ACS Publications
Caffeic acid is a plant-derived compound that is classified as hydroxycinnamic acid which
contains both phenolic and acrylic functional groups. Caffeic acid has been greatly …

Antibiotic combinations reduce Staphylococcus aureus clearance

V Lázár, O Snitser, D Barkan, R Kishony - Nature, 2022 - nature.com
The spread of antibiotic resistance is attracting increased attention to combination-based
treatments. Although drug combinations have been studied extensively for their effects on …

The physiology and genetics of bacterial responses to antibiotic combinations

R Roemhild, T Bollenbach, DI Andersson - Nature Reviews …, 2022 - nature.com
Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …