This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

The African continent is regarded as the cradle of modern humans and African genomes
contain more genetic variation than those from any other continent, yet only a fraction of the …

Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

INTRODUCTION Large-scale human genome-sequencing studies to date have been limited
to large, metropolitan populations or to small numbers of genomes from each group. Much …

The gut microbiomes of human populations worldwide have many core microbial species in
common. However, within a species, some strains can show remarkable population …

A remarkable exploration of the science, history, and politics of the Anthropocene, one of the
most important scientific ideas of our time, from two world-renowned experts Meteorites …

Southern Africa is consistently placed as a potential region for the evolution of Homo
sapiens. We present genome sequences, up to 13x coverage, from seven ancient …

Since the late Pleistocene, large-bodied mammals have been extirpated from much of Earth.
Although all habitable continents once harbored giant mammals, the few remaining species …

INTRODUCTION Genetic studies of the Pleistocene peopling of the Americas have focused
on the timing and number of migrations from Siberia into North America. They show that …