Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is
associated with mortality. This thrombocytopenia is characteristic of disseminated …

Recent studies have revealed that tumor-associated macrophages are the most abundant
stromal cells in the tumor microenvironment and play an important role in tumor initiation …

Summary Background The recent Sudan virus (SUDV) outbreak in Uganda highlights the
need for rapid response capabilities, including development of vaccines against emerging …

Obeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of
remdesivir (RDV) and is presently in phase 3 trials for COVID-19 treatment. In this work, we …

Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg
(MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates …

Lassa virus (LASV) is a World Health Organization (WHO) priority pathogen that causes high
morbidity and mortality. Recently, we showed that a combination of three broadly …

Abstract Background The family Filoviridae consists of several virus members known to
cause significant mortality and disease in humans. Among these, Ebola virus (EBOV) …

Zaire ebolavirus (EBOV), Sudan ebolavirus (SUDV) and Marburg virus (MARV), are
members of the Filoviridae family that can cause severe disease and death in humans and …

Although two vaccines for Zaire ebolavirus (EBOV) have been licensed and deployed
successfully to combat recurring outbreaks of Ebolavirus Disease in West Africa, there are …

Vaccines are needed to disrupt or prevent continued outbreaks of filoviruses in humans
across Western and Central Africa, including outbreaks of Marburg virus (MARV). As part of …