Protein lipidation describes a diverse class of post-translational modifications (PTMs) that is
regulated by over 40 enzymes, targeting more than 1,000 substrates at over 3,000 sites …

Immune checkpoint inhibitors (ICIs) therapy targeting programmed cell death ligand 1 (PD-
L1) and programmed death protein 1 (PD-1) had exhibited significant clinical benefits for …

Simple Summary Immunotherapy against PD-1/PD-L1 dramatically improved outcomes in
non-small cell lung cancer patients. These treatments are more effective the higher the …

As a potential antitumor drug and chemotherapeutic sensitizer, disulfiram combined with
Copper (DSF/Cu 2+) does not exert considerable antitumor effects on an immunocompetent …

The specific recognition of cancer cells by the body's immune system is an essential step in
initiating antitumor immunity. However, the decreased expression of major histocompatibility …

Reprogramming of lipid metabolism has received increasing recognition as a hallmark of
cancer cells because lipid dysregulation and the alteration of related enzyme profiles are …

Protein S-acylation is a prevalent post-translational protein lipidation that is dynamically
regulated by 'writer'protein S-acyltransferases and 'eraser'acylprotein thioesterases. The …

Blockade of programmed cell death-1/programmed cell death-ligand 1 (PD-L1) immune
checkpoints with monoclonal antibodies has shown great promise for cancer treatment, but …

Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of
patients who receive the most intensive treatment inevitably experience disease relapse …

Background Ferroptosis is an important iron‐dependent form of cell death in hepatocellular
carcinoma (HCC). Sorafenib, a potent ferroptosis inducer, is used to treat advanced HCC but …