Deep learning-based advances in protein structure prediction

SC Pakhrin, B Shrestha, B Adhikari, DB Kc - International journal of …, 2021 - mdpi.com
Obtaining an accurate description of protein structure is a fundamental step toward
understanding the underpinning of biology. Although recent advances in experimental …

[HTML][HTML] LZerD Protein-Protein Docking Webserver Enhanced With de novo Structure Prediction

C Christoffer, V Bharadwaj, R Luu… - Frontiers in molecular …, 2021 - frontiersin.org
Protein-protein docking is a useful tool for modeling the structures of protein complexes that
have yet to be experimentally determined. Understanding the structures of protein …

SPOT-Disorder2: improved protein intrinsic disorder prediction by ensembled deep learning

J Hanson, KK Paliwal, T Litfin… - Genomics, Proteomics …, 2019 - academic.oup.com
Intrinsically disordered or unstructured proteins (or regions in proteins) have been found to
be important in a wide range of biological functions and implicated in many diseases. Due to …

Residue-wise local quality estimation for protein models from cryo-EM maps

G Terashi, X Wang… - Nature …, 2022 - nature.com
An increasing number of protein structures are being determined by cryogenic electron
microscopy (cryo-EM). Although the resolution of determined cryo-EM density maps is …

Reaching alignment-profile-based accuracy in predicting protein secondary and tertiary structural properties without alignment

J Singh, K Paliwal, T Litfin, J Singh, Y Zhou - Scientific reports, 2022 - nature.com
Protein language models have emerged as an alternative to multiple sequence alignment
for enriching sequence information and improving downstream prediction tasks such as …

SPOT-Contact-LM: improving single-sequence-based prediction of protein contact map using a transformer language model

J Singh, T Litfin, J Singh, K Paliwal, Y Zhou - Bioinformatics, 2022 - academic.oup.com
Motivation Accurate prediction of protein contact-map is essential for accurate protein
structure and function prediction. As a result, many methods have been developed for …

Deeper profiles and cascaded recurrent and convolutional neural networks for state-of-the-art protein secondary structure prediction

M Torrisi, M Kaleel, G Pollastri - Scientific reports, 2019 - nature.com
Abstract Protein Secondary Structure prediction has been a central topic of research in
Bioinformatics for decades. In spite of this, even the most sophisticated ab initio SS …

[HTML][HTML] Catabolic profiling of selective enzymes in the saccharification of non-food lignocellulose parts of biomass into functional edible sugars and bioenergy: An in …

PK Paul, S Al Azad, MH Rahman… - Journal of advanced …, 2022 - ncbi.nlm.nih.gov
Objectives: The research aims to analyze the catabolic strength of different hydrolytic
enzymes in assessing the biological conversion potential of lignocellulose parts of …

OPUS-TASS: a protein backbone torsion angles and secondary structure predictor based on ensemble neural networks

G Xu, Q Wang, J Ma - Bioinformatics, 2020 - academic.oup.com
Motivation Predictions of protein backbone torsion angles (ϕ and ψ) and secondary
structure from sequence are crucial subproblems in protein structure prediction. With the …

SAINT: self-attention augmented inception-inside-inception network improves protein secondary structure prediction

MR Uddin, S Mahbub, MS Rahman, MS Bayzid - Bioinformatics, 2020 - academic.oup.com
Motivation Protein structures provide basic insight into how they can interact with other
proteins, their functions and biological roles in an organism. Experimental methods (eg X …