Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

The activation of the embryonic genome marks the first major wave of transcription in the
developing organism. Zygotic genome activation (ZGA) in mouse 2-cell embryos and 8-cell …

Gamete (sperm and oocyte) genomes are transcriptionally silent until embryonic genome
activation (EGA) following fertilization. EGA in humans had been thought to occur around the …

Abstract Poly (A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in
the oocyte-to-embryo transition (OET). Nothing is known about poly (A) tail dynamics during …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Obstetric and newborn outcomes of assisted reproductive technology (ART) pregnancies
are associated with significative prevalence of maternal and neonatal adverse health …

At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The
ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for …

During pre-implantation stages of mammalian development, maternally stored material
promotes both the erasure of the sperm and oocyte epigenetic profiles and is responsible for …

During formation of the preimplantation embryo several cellular and molecular milestones
take place, making the few cells forming the early embryo vulnerable to environmental …