Much recent attention has been directed toward the spatial organization of the cell nucleus
and the manner in which three-dimensional topologically associated domains and …

The use of assisted reproductive technologies is consistently rising across the world.
However, making an informed choice on which embryo culture medium should be preferred …

Remnants of transposable elements (TEs) are widely expressed throughout mammalian
embryo development. Originally infesting our genomes as selfish elements and acting as a …

The frequent acquisition of genomic abnormalities in human preimplantation embryos is a
leading cause of pregnancy loss, but does not necessarily prohibit healthy offspring …

The sperm energy restriction and recovery (SER) treatment developed in our laboratory was
shown to improve fertilization and blastocyst development following in vitro fertilization (IVF) …

According to birth certificates, the life of a child begins once their body comes out of the
mother's womb. But when does their organismal life begin? Science holds a palette of …

Mammalian development commences with the zygote, which can differentiate into both
embryonic and extraembryonic tissues, a capability known as totipotency. Only the zygote …

More than forty years after the first birth following in vitro fertilization (IVF), the success rates
of IVF and of IVF-derived assisted reproduction techniques (ART) still remain relatively low …

Not that long ago, the human genome was discovered to be mainly non-coding, that is
comprised of DNA sequences that do not code for proteins. The initial paradigm that non …

Highlights•Pioneer factors and histones prime the chromatin landscape for zygotic
transcription.•ZGA timing is regulated by nuclear-to-cytoplasmic (N/C) ratio and cell cycle …