An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

With the rapid development of biotechnology, the number of biological sequences has
grown exponentially. The continuous expansion of biological sequence data promotes the …

INTRODUCTION During development, a single-cell zygote undergoes repeated cell
divisions to produce an embryo that contains many distinct cell types. This sequence of cell …

Cell types are the basic building blocks of multicellular organisms and are extensively
diversified in animals. Despite recent advances in characterizing cell types, classification …

The human brain is a tissue of vast complexity in terms of the cell types it comprises.
Conventional approaches to classifying cell types in the human brain at single cell …

Kidneys have the capacity for intrinsic repair, preserving kidney architecture with return to a
basal state after tubular injury. When injury is overwhelming or repetitive, however, that …

Single-cell RNA-sequencing (scRNA-seq) has emerged as a revolutionary tool that allows
us to address scientific questions that eluded examination just a few years ago. With the …

Single-cell sequencing (SCS) has emerged as a powerful new set of technologies for
studying rare cells and delineating complex populations. Over the past 5 years, SCS …

Waddington's epigenetic landscape is an abstract metaphor frequently used to represent the
relationship between gene activity and cell fates during development. Over the past few …

Single-cell RNA-seq is a powerful technique. Nevertheless, there are important limitations,
including the technical challenges of breaking down an organ or tissue into a single-cell …