In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

The revolution in microbiota research over the past decade has provided invaluable
knowledge about the function of the microbial species that inhabit the human body. It has …

Allergies, including asthma, food allergy and atopic dermatitis, are increasing in prevalence,
particularly in westernized countries. Although a detailed mechanistic explanation for this …

Asthma is a common chronic respiratory disease affecting more than 300 million people
worldwide. Clinical features of asthma and its immunological and molecular etiology vary …

Asthma is a complex disease that often starts in childhood. Genomic and environmental
factors as well as aberrant immune maturation early in life can contribute to the onset of …

Environmental exposures interplay with human host factors to promote the development and
progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a …

In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their
importance in the pathophysiology of allergic diseases and their potential as biomarkers in …

Respiratory viral infections are the most important triggers of asthma exacerbations.
Rhinovirus (RV), the common cold virus, is clearly the most prevalent pathogen constantly …

Severe asthma in children is rare, accounting for only a small proportion of childhood
asthma. After addressing modifiable factors such as adherence to treatment, comorbidities …