Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Migraine is a debilitating neurological disorder affecting around one in seven people
worldwide, but its molecular mechanisms remain poorly understood. There is some debate …

Major depression is the commonest psychiatric disorder and in the US has the greatest
impact of all biomedical diseases on disability. Here we review evidence of the genetic …

Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have
met with limited success. We sought to increase statistical power to detect disease loci by …

Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …

Rare genetic variants contribute to complex disease risk; however, the abundance of rare
variants in human populations remains unknown. We explored this spectrum of variation by …

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Smoking is a leading global cause of disease and mortality. We established the Oxford-
GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP …