The major autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2,
are wildly expressed at the organ and tissue level. PKD1 encodes polycystin 1 (PC1), a …

Renal ciliopathies are a heterogenous group of inherited disorders leading to an array of
phenotypes that include cystic kidney disease and renal interstitial fibrosis leading to …

The human Sec61 complex is a widely distributed and abundant molecular machine. It
resides in the membrane of the endoplasmic reticulum to channel two types of cargo: protein …

Abstract Purpose of Review To provide a comprehensive update on the role of genetic
testing for the evaluation of kidney transplant recipient and living donor candidates. Recent …

Hepatocyte nuclear factor-1β (HNF-1β) is a DNA-binding transcription factor that is essential
for normal kidney development. Mutations of HNF1B in humans produce cystic kidney …

Mutations in approximately 80 genes have been implicated as the cause of various genetic
kidney diseases. However, gene delivery to kidney cells from the blood is inefficient …

Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick
ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the …

The clinical characteristics of autosomal dominant tubulointerstitial kidney disease (ADTKD)
include bland urinary sediment, slowly progressive chronic kidney disease (CKD) with many …

To elucidate the redundancy in the components for the targeting of membrane proteins to
the endoplasmic reticulum (ER) and/or their insertion into the ER membrane under …

Abstract Renal ischemia-reperfusion (IR)-induced tissue hypoxia causes impaired energy
metabolism and oxidative stress. These conditions lead to tubular cell damage, which is a …