噬菌体基因组中存在丰富的碱基修饰, 主要用于逃避宿主内切酶的切割. 40 多年前,
在蓝藻噬菌体S-2L 的DNA 中, 研究者发现2-氨基腺嘌呤(Z) 完全取代腺嘌呤(A), 与胸腺嘧啶(T) …

diaminopurine (Z), a naturally occurring noncanonical nucleotide base found in
bacteriophages, enhances DNA hybridization by forming three hydrogen bonds with …

Since bacteriophages (phages) were firstly reported at the beginning of the 20th century, the
study on them experiences booming-fading-emerging with discovery and overuse of …

Surface-enhanced Raman spectroscopy (SERS) coupled with density functional theory
(DFT) computations can characterise the adsorption orientation of a molecule on a …

Science 期刊于2021 年4 月30 日刊登了3 篇关于Z-基因组的研究论文. 本文将重点评论其中
赵素文, 张雁和赵惠民三个实验室的合作论文: 介绍多酶系统介导的Z-基因组生物合成 …

We show that the non-canonical nucleobase 2, 6-diaminopurine (D) spontaneously base
pairs with uracil (U) in water and the solid state without the need to be attached to the ribose …

[目的] 蓝藻(cyanobacteria) 水华频繁暴发, 引起水质恶化, 使水生生物大量死亡,
给水产养殖业造成巨大的经济损失; 其代谢产物藻毒素具有肝毒性, 神经毒性, 生殖毒性 …

2, 6-Diaminopurine (Z) is a naturally occurring adenine (A) analog that bacteriophages
employ in place of A in their genetic alphabet. Recent discoveries of biogenesis pathways of …

Cancer cells are believed to be recognized and controlled by the immune system of the host,
especially the adaptive immune system. Cancers may be initiated by a single gene defect in …

Bacteriophage genomes are the richest source of modified nucleobases of any life form. Of
these, 2, 6 diaminopurine, which pairs with thymine by forming three hydrogen bonds …